Evidence map›Paper›PMID 42181880›Full record

ArticleFrontiers in pharmacology2026

NAT2 rs1495741 and anti-tuberculosis drug-induced liver injury in children: genetic association and risk prediction.

Xin Huang, Jie Jiang, Li He, Yan Guo, Jianzhu Zhou, Hui Qiu, Haiyi Zhou, Xiaoyan Liu, Hanjie Yang, Chengxian Guo

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Article in Frontiers in pharmacology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

10 authors.

Xin HuangCenter of Clinical Pharmacology, The Third Xiangya Hospital, Central South University, Changsha, Hunan, China.
Jie JiangDepartment of Pediatrics, The Afffliated Changsha Central Hospital, Hengyang Medical School, University of South China, Changsha, China.
Li HeDepartment of Pediatrics, The Third Xiangya Hospital of Central South University, Changsha, China.
Yan GuoHunan Normal University School of Medicine, Changsha, Hunan, China.
Jianzhu ZhouCenter of Clinical Pharmacology, The Third Xiangya Hospital, Central South University, Changsha, Hunan, China.
Hui QiuCenter of Clinical Pharmacology, The Third Xiangya Hospital, Central South University, Changsha, Hunan, China.
Haiyi ZhouDepartment of Pediatrics, The Afffliated Changsha Central Hospital, Hengyang Medical School, University of South China, Changsha, China.
Xiaoyan LiuDepartment of Pediatrics, The Afffliated Changsha Central Hospital, Hengyang Medical School, University of South China, Changsha, China.
Hanjie YangDepartment of Pediatrics, The Afffliated Changsha Central Hospital, Hengyang Medical School, University of South China, Changsha, China.
Chengxian GuoCenter of Clinical Pharmacology, The Third Xiangya Hospital, Central South University, Changsha, Hunan, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Anti-tuberculosis drug-induced liver injury (ATB-DILI) is a major adverse event in children receiving anti-tuberculosis therapy, but pediatric pharmacogenetic evidence remains limited. Methods: We studied 192 children receiving anti-tuberculosis treatment, including 31 with ATB-DILI and 161 without DILI. After quality control, 86 single-nucleotide polymorphisms were tested for association with ATB-DILI. Based on three available NAT2 variants, NAT2 diplotypes were inferred from the genotype data, and acetylator phenotypes were determined. The relationship of rs1495741 with 2-h plasma isoniazid concentration and ATB-DILI was further evaluated, and prediction models integrating genetic and clinical variables were developed. Results: After Bonferroni correction, only NAT2 rs1495741 remained significantly associated with ATB-DILI ( Conclusion: NAT2 rs1495741 was strongly associated with pediatric ATB-DILI risk and showed high concordance with inferred NAT2 acetylator phenotypes. This association was not significantly mediated by the measured single 2-h plasma isoniazid concentration in this dataset. Incorporating rs1495741 may improve risk stratification in children.

Indexed as

anti-tuberculosis drug-induced liver injurycausal mediation analysischildrenisoniazidmachine learningNAT2 polymorphism

Identifiers

PMID42181880
PMCPMC13195251

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