ArticleFrontiers in pharmacology2026
Toward high-stability quantitative carriers: development of superparamagnetic nanocarriers and a high-sensitivity mixing-frequency narrow-band magnetic particle imaging detection system.
Article in Frontiers in pharmacology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Introduction: Superparamagnetic iron oxide nanoparticles (SPIONs) have attracted extensive attention in recent years as visualizable and controllable organic nanocarriers. Magnetic particle imaging (MPI), as a quantitative imaging method, enables visual and quantitative characterization of carriers. The quantitative imaging capability of carriers is critically crucial for precise quantitative local drug concentrations. However, the alternating current susceptibility (ACS) of SPIONs is highly susceptible to external interference and, thus, prone to fluctuations, which tend to be multifactorial and poorly defined in the Methods: Through the analysis of the third-harmonic ACS of SPIONs, we proposed that under specific nanoscale dimensions and instrument frequency, the ACS maintained a relatively stable state, with a quantifiable fluctuation range even under complex interference conditions, thus enabling quantitative analysis in the Results and Discussion:
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