Evidence map›Paper›PMID 42181794›Full record

ArticleJHLT open2026

Right ventricular-pulmonary arterial coupling may discriminate late right heart failure outcomes in left ventricular assist device recipients.

Alexandra I Mansour, Bhavya Ancha, Fatimah Alkhunaizi, Yoo Jin Kim, Wendy Foy, Steven Keller, Antonio Polanco, Chetan Pasrija, Ahmet Kilic, Ryan J Tedford and 2 more

Abstract read
In one paragraph

Article in JHLT open, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Alexandra I MansourJohns Hopkins University Division of Cardiology, DOM, Baltimore, Maryland.
Bhavya AnchaJohns Hopkins University Division of Cardiology, DOM, Baltimore, Maryland.
Fatimah AlkhunaiziJohns Hopkins University Division of Cardiology, DOM, Baltimore, Maryland.
Yoo Jin KimJohns Hopkins University Division of Cardiology, DOM, Baltimore, Maryland.
Wendy FoyJohns Hopkins University Division of Cardiology, DOM, Baltimore, Maryland.
Steven KellerJohns Hopkins University Division of Pulmonary & Crit. Care Medicine, DOM, Baltimore, Maryland.
Antonio PolancoJohns Hopkins University Division of Cardiothoracic Surgery, Dept of Surgery, Baltimore, Maryland.
Chetan PasrijaJohns Hopkins University Division of Cardiothoracic Surgery, Dept of Surgery, Baltimore, Maryland.
Ahmet KilicJohns Hopkins University Division of Cardiothoracic Surgery, Dept of Surgery, Baltimore, Maryland.
Ryan J TedfordMedical University of South Carolina Division of Cardiology, Charleston, South Carolina.
Paul ScheelJohns Hopkins University Division of Cardiology, DOM, Baltimore, Maryland.
Steven HsuJohns Hopkins University Division of Cardiology, DOM, Baltimore, Maryland.

Funding

Myocyte Mechanics of Right Ventricular Contractile Failure in Pulmonary Hypertension due to Heart Failure with Reduced Ejection FractionR01HL172830 · NHLBI · JOHNS HOPKINS UNIVERSITY · PI Steven Hsu · 2024 to 2026
$2.0M
NHLBI NIH HHS R01 HL172830
6 · The paper itself

Abstract

Right ventricular-pulmonary arterial (RV-PA) coupling more sensitively captures RV dysfunction and may identify those at risk for late right heart failure (LRHF). Fourteen left ventricular assist device patients underwent prospective RV pressure-volume loop assessment and outcome adjudication. RV-PA coupling was indexed by the ratio of pressure-volume-derived RV end-systolic elastance (Ees) to pulmonary arterial elastance (Ea). Receiver operating curves compared the ability of Ees/Ea with standard hemodynamic metrics to discriminate LRHF outcomes. Freedom from LRHF or cardiovascular-related death was compared between those above and below the Ees/Ea value with optimal sensitivity and specificity for LRHF (Ees/Ea = 0.36). Ees/Ea best discriminated LRHF outcomes (AUC 0.92;

Indexed as

hemodynamicslate right heart failureleft ventricular assist devicepressurevolume loop

Identifiers

PMID42181794
PMCPMC13196536

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.