ArticleHardwareX2026
Motilitometer: A compact modular microscope for motility and photoresponse analysis of microorganisms.
Article in HardwareX, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
4 authors.
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Abstract
In biology, cell motility is a valuable indicator, revealing how cells sense their environment, adapt to stimuli, and reflect their physiological state. In this paper, we present a modular microscopy system designed to study the motility of microorganisms. The setup is compact, assembled from low-cost 3D-printed and widely available components. It integrates programmable multispectral illumination to enable controlled photo stimulation and investigation of light-induced behavioral responses, including phototaxis. Initially developed for the investigation of photosynthetic microalgae, the system is easily adaptable to a wide range of motile microorganisms. It supports two complementary observation modes: a droplet-based chamber that minimizes sedimentation for cell speed analysis, and a deeper chamber that allows sedimentation, enabling quantitative assessment of motility fraction and orientation relative to directional light. The optical system provides a magnification of up to approximately 9×, sufficient for the precise centroid detection and tracking of single cells. This open-source, DIY (Do It Yourself) microscopy platform offers an accessible tool for photobiology, microbial ecology, and biophysics, helping democratize quantitative motility studies.
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Registered trials
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