Evidence map›Paper›PMID 42181749›Full record

ArticleTransboundary and emerging diseases2026

ROP16 Promotes Epithelial-Mesenchymal Transition-Like Changes in Ocular Toxoplasmosis via STAT3 and TGF-β1 Pathways.

Lingling Song, Lihui Xu, Yao Liu, Yun Yang, Cong Wang, Ya Zhang, Qingli Luo, Yuanyuan Cao, Yong Wang, Li Yu

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Transboundary and emerging diseases, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Lingling SongDepartment of Microbiology and Parasitology, Anhui Provincial Key Laboratory of Zoonoses, School of Basic Medical Sciences, Anhui Medical University, Hefei, Anhui, China, ahmu.edu.cn.ORCID https://orcid.org/0009-0009-3805-952X
Lihui XuDepartment of Microbiology and Parasitology, Anhui Provincial Key Laboratory of Zoonoses, School of Basic Medical Sciences, Anhui Medical University, Hefei, Anhui, China, ahmu.edu.cn.ORCID https://orcid.org/0009-0002-9818-5316
Yao LiuDepartment of Microbiology and Parasitology, Anhui Provincial Key Laboratory of Zoonoses, School of Basic Medical Sciences, Anhui Medical University, Hefei, Anhui, China, ahmu.edu.cn.ORCID https://orcid.org/0009-0000-3627-2989
Yun YangDepartment of Microbiology and Parasitology, Anhui Provincial Key Laboratory of Zoonoses, School of Basic Medical Sciences, Anhui Medical University, Hefei, Anhui, China, ahmu.edu.cn.ORCID https://orcid.org/0009-0000-3337-3872
Cong WangDepartment of Microbiology and Parasitology, Anhui Provincial Key Laboratory of Zoonoses, School of Basic Medical Sciences, Anhui Medical University, Hefei, Anhui, China, ahmu.edu.cn.ORCID https://orcid.org/0009-0006-9280-1666
Ya ZhangDepartment of Ophthalmology, The First Affiliated Hospital of Anhui Medical University, Hefei, Anhui, China, ahmu.edu.cn.ORCID https://orcid.org/0009-0006-6787-3393
Qingli LuoDepartment of Microbiology and Parasitology, Anhui Provincial Key Laboratory of Zoonoses, School of Basic Medical Sciences, Anhui Medical University, Hefei, Anhui, China, ahmu.edu.cn.ORCID https://orcid.org/0009-0003-5629-8731
Yuanyuan CaoDepartment of Microbiology and Parasitology, Anhui Provincial Key Laboratory of Zoonoses, School of Basic Medical Sciences, Anhui Medical University, Hefei, Anhui, China, ahmu.edu.cn.ORCID https://orcid.org/0009-0003-8598-2516
Yong WangDepartment of Ophthalmology, The First Affiliated Hospital of Anhui Medical University, Hefei, Anhui, China, ahmu.edu.cn.ORCID https://orcid.org/0009-0002-7691-5066
Li YuDepartment of Microbiology and Parasitology, Anhui Provincial Key Laboratory of Zoonoses, School of Basic Medical Sciences, Anhui Medical University, Hefei, Anhui, China, ahmu.edu.cn.ORCID https://orcid.org/0000-0001-5813-0842

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Toxoplasmosis is a globally significant infectious disease, affecting approximately one-third of the world's population. Ocular toxoplasmosis (OT) is a major and vision-threatening clinical manifestation. However, its pathogenesis remains elusive, and effective targeted therapies are unavailable. This study demonstrates that

Indexed as

Epithelial-Mesenchymal TransitionProtozoan ProteinsSTAT3 Transcription FactorToxoplasmosis, OcularTransforming Growth Factor beta1AnimalsCell LineFemaleHumansMiceProtein-Tyrosine KinasesSignal TransductionToxoplasmaProtein-Tyrosine KinasesProtozoan ProteinsRop16 protein, Toxoplasma gondiiSTAT3 Transcription FactorTransforming Growth Factor beta1EMT-like changesOTROP16STAT3TGF-β1Toxoplasma gondii

Identifiers

PMID42181749
PMCPMC13197621

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.