ArticleOphthalmology science2026
Cystoid Macular Edema in Retinitis Pigmentosa: Pathophysiologic Insight Using Swept-Source OCT and Angiography.
Article in Ophthalmology science, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Objective: Cystoid macular edema (CME) is relatively common in patients with retinitis pigmentosa (RP), but its pathophysiology is poorly understood. This study aims to provide insight into pathophysiologic mechanisms of CME formation using swept-source (SS) OCT angiography (OCTA). Design: Retrospective cross-sectional study at a tertiary referral center. Participants: Seventy consecutive patients with molecularly confirmed RP (associated with Methods: All patients underwent complete ophthalmic examination with multimodal imaging, including SS-OCT with SS-OCTA (PLEX Elite 9000). Images were then analyzed in a semiautomated fashion using ImageJ. Main Outcome Measures: Structural and vascular abnormalities seen on SS-OCT and SS-OCTA in patients with RP, and spatial overlap between CME areas, vascular flow loss in the deep capillary plexus (DCP), and preserved external limiting membrane (ELM) and ellipsoid zone (EZ). Results: One hundred twenty-nine eyes from 70 patients (mean age 37 years, range 6 to 78) with molecularly confirmed RP were included. The mean best-corrected visual acuity measured 0.35 logarithm of the minimum angle of resolution (range -0.12 to 2.7). Overall, 31% of patients had CME (10% in Conclusions: Cystoid macular edema is relatively common in RP, with different prevalence depending on genotype. There is strong spatial overlap between areas of DCP loss and ELM preservation regardless of genotype, suggesting a shared mechanism of impaired fluid clearance at the level of the DCP. Financial Disclosures: The author has no/the authors have no proprietary or commercial interest in any materials discussed in this article.
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