ArticleClinical, cosmetic and investigational dermatology2026
Microneedling Combined with Photothermal-Biomodulated Autologous PRP to Enhance Exosome Release in Refractory Melasma: A Case Report.
Article in Clinical, cosmetic and investigational dermatology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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2 authors.
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Abstract
Melasma is a challenging condition to treat, requiring multiple therapeutic approaches. Exosomes have been used as regenerative therapies in diverse contexts, including dermatological disorders. A 35-year-old male patient with Fitzpatrick skin phototype II and a longstanding diagnosis of facial melasma, who had undergone multiple prior treatments - including topical agents and laser therapy - with little to no improvement was treated with three monthly sessions of robotic microneedling without radiofrequency on the melasma-affected areas, followed by the injection of preconditioned autologous platelet-rich plasma. The preconditioning consisted of photothermal biomodulation using the Meta Cell Technology technique, applying blue light (467 nm), 1 J/cm
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