Evidence map›Paper›PMID 42181650›Full record

ArticleFrontiers in cardiovascular medicine2026

Development and validation of a prediction model for 1-year all-cause rehospitalisation after discharge in patients with heart failure with preserved ejection fraction based on the systemic immune-inflammation index.

Pan Chen, Xiaoyan Yin, Boshi Liu, Lei Ren

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Article in Frontiers in cardiovascular medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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5 · Who and what money

Authors and funding

4 authors.

Pan ChenDepartment of Cardiovascular Medicine, Anhui Medical University Affiliated Fuyang People's Hospital, Fuyang People's Hospital, Fuyang, Anhui, China.
Xiaoyan YinDepartment of Cardiovascular Medicine, Bengbu Medical University Affiliated Fuyang Hospital, Fuyang People's Hospital, Fuyang, Anhui, China.
Boshi LiuDepartment of Cardiovascular Medicine, Anhui Medical University Affiliated Fuyang People's Hospital, Fuyang People's Hospital, Fuyang, Anhui, China.
Lei RenDepartment of Cardiovascular Medicine, Anhui Medical University Affiliated Fuyang People's Hospital, Fuyang People's Hospital, Fuyang, Anhui, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objective: To develop and internally validate a practical model for predicting the risk of at least one all-cause rehospitalisation within 1 year after discharge in patients with heart failure with preserved ejection fraction (HFpEF), with particular attention to the systemic immune-inflammation index (SII). Methods: This single-center observational study was based on retrospective analysis of index-admission data and follow-up records from patients with HFpEF treated at Fuyang People's Hospital between January 2022 and January 2024. Among 341 initially eligible patients, 29 were lost to follow-up, leaving a final analytic cohort of 312 patients. The cohort was divided into a training set ( Results: LnSII, LnNT-proBNP, LnLp(a), GFR, and hypertension remained in the final model. The model showed good discrimination, with an area under the receiver operating characteristic curve of 0.8468 in the training set and 0.8302 in the validation set. At the optimal cutoff derived from the training set, sensitivity and specificity were 0.7101 and 0.8993 in the training set and 0.5333 and 0.8750 in the validation set, respectively. Calibration was acceptable in both cohorts according to the Hosmer-Lemeshow test, and decision curve analysis suggested potential clinical utility. Conclusion: A 5-variable model incorporating LnSII, LnNT-proBNP, LnLp(a), GFR, and hypertension showed good discrimination, acceptable calibration, and potential clinical usefulness for predicting 1-year all-cause rehospitalisation after discharge in patients with HFpEF. External validation is needed before broader application.

Indexed as

all-cause rehospitalisationheart failure with preserved ejection fractionnomogramprognosissystemic immune-inflammation index

Identifiers

PMID42181650
PMCPMC13194563

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