ArticleFrontiers in pediatrics2026
Multi-omics integration reveals BPGM downregulation and potential plasma metabolite biomarkers for childhood asthma.
Article in Frontiers in pediatrics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Objective: This study aimed to identify potential diagnostic biomarkers and candidate therapeutic targets through multi-omics integration of peripheral blood transcriptomics and metabolomics in children with asthma. We specifically investigated the association between bisphosphoglycerate mutase (BPGM) downregulation and metabolic alterations in the glycine-serine-threonine pathway, seeking to explore potential mechanisms underlying asthma-related metabolic reprogramming. Methods: In this exploratory multi-omics study, we integrated public transcriptomic data (GSE35571, Results: Transcriptomics identified 15 differentially expressed genes ( Conclusions: This preliminary multi-omics integration study identified concurrent BPGM downregulation and altered glycine-serine-threonine metabolism in childhood asthma. While these findings suggest a potential association between BPGM expression changes and metabolic alterations in this pathway, the proposed mechanistic link remains hypothetical and requires direct experimental validation.
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