Construction of a nomogram combining CT and serum markers for predicting macrolide resistance gene mutation status in pediatric Mycoplasma pneumoniae pneumonia.

Xinhui Yuan, Rui Xin, Lifang Wang, Jizu Ling, Yumei Li, Lihong Pang

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Article in Frontiers in pediatrics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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6 authors.

Xinhui YuanDepartment of Pediatrics, the First Hospital of Lanzhou University, The First Clinical Medical College of Lanzhou University, Lanzhou, Gansu Province, China.

Rui XinDepartment of Pediatrics, the First Hospital of Lanzhou University, The First Clinical Medical College of Lanzhou University, Lanzhou, Gansu Province, China.

Lifang WangDepartment of Pediatrics, the First Hospital of Lanzhou University, The First Clinical Medical College of Lanzhou University, Lanzhou, Gansu Province, China.

Jizu LingDepartment of Pediatrics, the First Hospital of Lanzhou University, The First Clinical Medical College of Lanzhou University, Lanzhou, Gansu Province, China.

Yumei LiDepartment of Pediatrics, the First Hospital of Lanzhou University, The First Clinical Medical College of Lanzhou University, Lanzhou, Gansu Province, China.

Lihong PangDepartment of Pediatrics, the First Hospital of Lanzhou University, The First Clinical Medical College of Lanzhou University, Lanzhou, Gansu Province, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Purpose: To develop and validate a nomogram integrating chest computed tomography (CT) features and serum biomarkers for predicting the mutation status of macrolide resistance genes in pediatric Mycoplasma pneumoniae pneumonia (MPP). Methods: This retrospective study enrolled children diagnosed with MPP, genetically stratified into macrolide-resistant (MRMP) and macrolide-sensitive (MSMP) groups based on 23S rRNA gene mutations (A2063G/A2064G). Clinical data, chest CT scans obtained within 48 h of admission, and serum biomarker levels (including C-reactive protein [CRP], procalcitonin [PCT], interleukin-6 [IL-6], D-dimer, neutrophil-to-lymphocyte ratio [NLR], and lactate dehydrogenase to albumin ratio [LAR]) measured within 24 h of admission prior to antibiotic therapy were analyzed. Results: Compared to the MSMP group ( Conclusion: A nomogram combining CT imaging characteristics and serum biomarkers predicted mutation status of macrolide resistance genes in pediatric MPP, potentially aiding early clinical decision-making.

Indexed as

biomarkerscomputed tomographymacrolide resistanceMycoplasma pneumoniaenomogram

Identifiers

PMID42181565

DOI10.3389/fped.2026.1828908

PMCPMC13194381

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