ArticleCureus2026
Silent Aggressor: Unveiling Large-Cell Duodenal Neuroendocrine Carcinoma.
Article in Cureus, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Duodenal neuroendocrine neoplasms (D-NENs) are uncommon tumors that account for a fraction of duodenal tumors. Although often incidentally discovered, those in the ampullary or peri-ampullary regions may present with symptoms due to biliary or gastrointestinal obstruction, including obstruction or bleeding. We describe a 65-year-old male who presented with fatigue, altered mentation, and melena. His evaluation was notable for severe anemia, metabolic derangements, and laboratory findings with concern for tumor lysis syndrome. Emergent management with hemodialysis and supportive care stabilized his condition. Esophagogastroduodenoscopy revealed a Forrest class 1B duodenal ulcer and histopathological examination of obtained biopsies confirmed a diagnosis of large-cell neuroendocrine carcinoma with a Ki-67 index of approximately 80%. Subsequent imaging demonstrated extensive hepatic involvement. Given the advanced stage of the disease and after multidisciplinary discussion, the patient elected against further oncologic intervention. This case highlights the diagnostic challenges and aggressive nature of high-grade D-NENs, emphasizing the importance of early recognition and a multidisciplinary treatment approach.
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