Evidence map›Paper›PMID 42181402›Full record

ArticleCureus2026

The Impact of an Engagement Solution Incorporating Antihypertensive Medications, Engagement Tools, and a Digital Application on Adherence Among Hypertensive Patients: A Real-World Study.

Erika M Goncalves Campana, Rodrigo J De Castro Sepetiba, Felipe R Pacheco De Souza, Gustavo Mantovani Pucci, Paulo H Gasques Trovati, Sayuri Inuzuka, Paulo C Ferraz Dias Filho, Marselha Marques Barral Montessi, Vitor B Teixeira de Holanda, Bruno A Alcova Nogueira and 4 more

Abstract read
In one paragraph

Article in Cureus, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Erika M Goncalves CampanaDepartment of Cardiology, Universidade do Estado do Rio de Janeiro, Niterói, BRA.
Rodrigo J De Castro SepetibaDepartment of Cardiology, Universidade Federal de Santa Catarina ( UFSC), Santa Catarina, BRA.
Felipe R Pacheco De SouzaDepartment of Cardiology, Policlínica Metropolitana do Estado do Pará, Belém, BRA.
Gustavo Mantovani PucciDepartment of Cardiology, Cor e Ar Centro Cardio Respiratório, São Paulo, BRA.
Paulo H Gasques TrovatiDepartment of Cardiology, Clínica Santoro (Itu-SP), São Paulo, BRA.
Sayuri InuzukaDepartment of Cardiology, Universidade Federal de Goiás, Goiana, BRA.
Paulo C Ferraz Dias FilhoDepartment of Cardiology, Hospital São Domingos, São Luis, BRA.
Marselha Marques Barral MontessiDepartment of Cardiology, Faculdade de Ciências Médicas e da Saúde de Juiz de Fora, Juiz de Fora, BRA.
Vitor B Teixeira de HolandaDepartment of Cardiology, Universidade Estadual do Pará, Belém, BRA.
Bruno A Alcova NogueiraDepartment of Cardiology, Clínica Coração Vivo, São José dos Campos, BRA.
Lays Paulino LeonelDepartment of Data Analysis, IQVIA Solutions Brazil, São Paulo, BRA.
Renato De Lima VitorassoDepartment of Data Analysis, IQVIA Solutions Brazil, São Paulo, BRA.
Marcella Chaves FloresDepartment of Medical Affairs, Servier Brazil, Rio de Janeiro, BRA.
Mayara L Da SilvaDepartment of Medical Affairs, Servier Brazil, Rio de Janeiro, BRA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundHypertension is the leading preventable risk factor for cardiovascular disease. The lack of treatment adherence is one of the most important challenges in managing and controlling hypertension. It is unclear whether patient-focused strategies and training for doctors are associated with better adherence and control.

objectiveThis study aimed to evaluate treatment adherence among hypertensive patients by comparing a group of patients who were part of a patient support program (PSP) and were using the engagement solution (ES), i.e., antihypertensive medications, engagement tools, and the Elfie application. These patients were included in group A by trained physicians. Group B features patients who were also part of the program but were using only medications.

methodsThis observational and retrospective study analyzed data from the PSP Sempre Cuidando (Laboratórios Servier do Brasil, Rio de Janeiro, BRA) and the Elfie app (Elfie, SGP), collected from across Brazil between November 2022 and October 2023. The population included hypertensive patients aged 18 years or older with arterial hypertension and possessing a medical prescription for antihypertensives referenced in the PSP. RESULTS AND

conclusionPatients were divided into two groups: 492 in group A and 984 in group B. The two groups were followed for six months. Group A demonstrated higher adherence to treatment, with an average treatment duration of 3.7 months compared to 2.7 months in group B, representing a 37% increase. Additionally, patients in group A showed statistically significant reductions in systolic blood pressure (SBP) and diastolic blood pressure (DBP) after six months versus their baseline.

conclusionsThe engagement solution was associated with higher levels of adherence and improved blood pressure control among hypertensive patients.

Indexed as

database management systemsdigital healthhypertensionmedication adherencepatient-centered care

Identifiers

PMID42181402
PMCPMC13198424

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.