ArticleBiological psychiatry global open science2026
Genetic Pathways Point to the Biology Underlying the Association Between Cannabis Use Disorder and Psychosis.
Article in Biological psychiatry global open science, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- Cannabis and Psychosis: Genomic Methods Shed Light on Pathophysiological Processes.Biological psychiatry global open science · 2026Article
- Integrating biological pathway polygenic scores and trauma in psychosis: findings from the EU-GEI study.Translational psychiatry · 2026Article
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Authors and funding
16 authors.
Funding
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Abstract
Background: Cannabis use is associated with increased risk of psychotic disorders, but the underlying biological mechanisms remain unclear. We used genetic data to investigate the molecular pathways contributing to the association between cannabis use disorder (CUD) and psychosis. Methods: We conducted a cross-disorder meta-analysis of genome-wide association studies (GWASs) on schizophrenia and bipolar I disorder ( Results: We identified 553 independent genome-wide significant loci for psychosis, including 122 novel associations. More pathways were nominally associated with psychosis and CUD than expected by chance. MR analyses supported bidirectional causal effects (psychosis on CUD β Conclusions: Our findings highlight shared and distinct molecular pathways linking CUD and psychosis. Glutamate signaling emerged as a key mechanism across analysis strategies, while MR-CLUST revealed heterogeneous causal routes from cannabis use to psychosis. These insights may inform risk prediction and targeted interventions for cannabis-related psychosis.
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