Evidence map›Paper›PMID 42181268›Full record

ArticleiScience2026

Instant fluorescence lifetime imaging microscopy reveals mechano-metabolic reprogramming of stromal cells in breast peritumor microenvironment.

Julian Najera, Hao Chen, Bianca Batista, Frank Ketchum, Aktar Ali, Pinar Zorlutuna, Scott Howard, Meenal Datta

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in iScience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors.

Julian NajeraDepartment of Aerospace and Mechanical Engineering, University of Notre Dame, Notre Dame, IN 46556, USA.
Hao ChenDepartment of Electrical Engineering, University of Notre Dame, Notre Dame, IN 46556, USA.
Bianca BatistaDepartment of Aerospace and Mechanical Engineering, University of Notre Dame, Notre Dame, IN 46556, USA.
Frank KetchumDepartment of Aerospace and Mechanical Engineering, University of Notre Dame, Notre Dame, IN 46556, USA.
Aktar AliDepartment of Chemistry and Biochemistry, University of Notre Dame, Notre Dame, IN 46556, USA.
Pinar ZorlutunaDepartment of Aerospace and Mechanical Engineering, University of Notre Dame, Notre Dame, IN 46556, USA.
Scott HowardBioengineering Graduate Program, University of Notre Dame, Notre Dame, IN 46556, USA.
Meenal DattaDepartment of Aerospace and Mechanical Engineering, University of Notre Dame, Notre Dame, IN 46556, USA.

Funding

Establishing an immune mechanomeR35GM151041 · NIGMS · UNIVERSITY OF NOTRE DAME · PI Meenal Datta · 2023 to 2026
$1.7M
NIGMS NIH HHS R35 GM151041
6 · The paper itself

Abstract

The breast peritumor microenvironment (pTME) is increasingly recognized as a mediator of breast cancer progression and treatment resistance. However, how tumor compressive forces (i.e., solid stresses) influence it remains unclear. Using instant fluorescence lifetime imaging microscopy (FLIM), we show that

Indexed as

health sciencesmedicinemicroenvironmentoncology

Identifiers

PMID42181268
PMCPMC13196570

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.