Evidence map›Paper›PMID 42181265›Full record

ArticleiScience2026

Huntingtin polyglutamine expansions misdirect axonal transport by perturbing motor and adaptor recruitment.

Emily N P Prowse, Brooke A Turkalj, Muriel Sébastien, Lale Gursu, Daniel Beaudet, Jia Feng, Chengqian Zhou, Heidi M McBride, Gary J Brouhard, Mahmoud A Pouladi and 1 more

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In one paragraph

Article in iScience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Emily N P ProwseDepartment of Bioengineering, McGill University, Montréal, QC, Canada.
Brooke A TurkaljDepartment of Bioengineering, McGill University, Montréal, QC, Canada.
Muriel SébastienDepartment of Bioengineering, McGill University, Montréal, QC, Canada.
Lale GursuDepartment of Bioengineering, McGill University, Montréal, QC, Canada.
Daniel BeaudetDepartment of Bioengineering, McGill University, Montréal, QC, Canada.
Jia FengDepartment of Medical Genetics, University of British Columbia, Vancouver, BC, Canada.
Chengqian ZhouDepartment of Bioengineering, McGill University, Montréal, QC, Canada.
Heidi M McBrideDepartment of Neurology and Neurosurgery, Montreal Neurological Institute, McGill University, Montréal, QC, Canada.
Gary J BrouhardDepartment of Biology, McGill University, Montréal, QC, Canada.
Mahmoud A PouladiDepartment of Medical Genetics, University of British Columbia, Vancouver, BC, Canada.
Adam G HendricksDepartment of Bioengineering, McGill University, Montréal, QC, Canada.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Huntington's disease is caused by polyglutamine (polyQ) expansions in huntingtin (HTT). PolyQ lengths >35Q lead to neurodegeneration, and longer repeats correspond to earlier onset of symptoms. HTT scaffolds kinesin-1 and dynein to organelles directly and through adaptors. We tracked BDNF vesicles, mitochondria, and lysosomes in stem-cell-derived neurons engineered to express HTT with polyQ lengths of 30, 45, 65, and 81. BDNF endosomes were more motile in HTT-45Q and HTT-65Q neurons and misdirected toward the distal tip in HTT-81Q neurons. Under neuroinflammatory stress, polyQ expansions resulted in fewer BDNF cargoes and more lysosomes. We next isolated BDNF endosomes from neurons and counted the associated motors and adaptors. We found BDNF endosomes associated with greater numbers of kinesin-1 and HAP1 molecules in HTT-81Q neurons. Together, these results show that polyQ expansions in HTT alter the motors and adaptors recruited to cargoes, resulting in dysregulated transport and responses to neuroinflammatory stress.

Indexed as

Cellular neuroscienceMolecular networkMolecular neuroscience

Identifiers

PMID42181265
PMCPMC13194641

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.