ArticleiScience2026
The modulation of AUF1 regulates the R-loop resolution activating the immune response in DDR.
Article in iScience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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15 authors.
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Abstract
The DNA damage response (DDR) is a global cellular process that affects multiple cellular compartments, including the tumor microenvironment (TME). After DNA damage, unrepaired DNA fragments or DNA-RNA hybrids can be exported from the nucleus to the cytoplasm, where they activate immune responses, suggesting a new potential readout for cancer therapy. We previously showed that loss of AUF1, an RNA-binding protein, impairs homologous recombination by promoting the accumulation of R -loops. In this study, we investigate the role of AUF1 in DNA repair and immune activation. We demonstrate that AUF1 deregulation leads to accumulation and cytoplasmic export of R loops following DNA damage, resulting in activation of the cGAS-STING signaling pathway. These findings highlight the critical role of R loops in maintaining genome stability and reveal how their deregulation links defective DNA repair to innate immune signaling, opening to a possible therapeutic relevance for cancer.
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