ReviewiScience2026
Mechanistic insights into subclinical
Review in iScience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Detection ofASM case reports · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Subclinical malaria presents a challenge to global malaria elimination efforts. It often evades detection by conventional diagnostic tools due to low parasite densities. Despite being clinically silent, asymptomatic infections within the broader spectrum of subclinical malaria serve as hidden reservoirs that sustain transmission. Their persistence arises from a multifaceted interplay of parasite adaptations, including density thresholds, antigenic variation, cytoadhesion, multiplicity of infection, and emerging drug resistance, and host-related factors such as naturally acquired immunity, age, pregnancy, genetic polymorphisms, and epigenetic influences. Chronic subclinical and asymptomatic infections are associated with anemia, impaired cognitive development in children, and adverse pregnancy outcomes. This article examines the epidemiological burden, biological mechanisms, diagnostic challenges, and health consequences of subclinical malaria. The urgent need for field-deployable, sensitive diagnostic tools and integrative approaches is underscored. Understanding the mechanisms sustaining subclinical and asymptomatic infections is essential for targeted interventions and malaria elimination.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.