Evidence map›Paper›PMID 42181233›Full record

ArticleiScience2026

Progression of nipah virus infection in the African green monkey: Role of macrophages and dendritic cells in early virus spread.

Karla A Fenton, Jacquelyn Turcinovic, Abhishek N Prasad, Krystle N Agans, Viktoriya Borisevich, Daniel J Deer, Alyssa C Fears, Natalie S Dobias, Christopher C Broder, Robert W Cross and 2 more

Abstract read
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In one paragraph

Article in iScience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Karla A FentonGalveston National Laboratory, University of Texas Medical Branch, Galveston, TX, USA.
Jacquelyn TurcinovicGalveston National Laboratory, University of Texas Medical Branch, Galveston, TX, USA.
Abhishek N PrasadGalveston National Laboratory, University of Texas Medical Branch, Galveston, TX, USA.
Krystle N AgansGalveston National Laboratory, University of Texas Medical Branch, Galveston, TX, USA.
Viktoriya BorisevichGalveston National Laboratory, University of Texas Medical Branch, Galveston, TX, USA.
Daniel J DeerGalveston National Laboratory, University of Texas Medical Branch, Galveston, TX, USA.
Alyssa C FearsGalveston National Laboratory, University of Texas Medical Branch, Galveston, TX, USA.
Natalie S DobiasGalveston National Laboratory, University of Texas Medical Branch, Galveston, TX, USA.
Christopher C BroderDepartment of Microbiology and Immunology, Uniformed Services University, Bethesda, MD 20814, USA.
Robert W CrossGalveston National Laboratory, University of Texas Medical Branch, Galveston, TX, USA.
Courtney WoolseyGalveston National Laboratory, University of Texas Medical Branch, Galveston, TX, USA.
Thomas W GeisbertGalveston National Laboratory, University of Texas Medical Branch, Galveston, TX, USA.

Funding

UTMB Women's Health Research Scholars ProgramK12AR084228 · NIAMS · UNIVERSITY OF TEXAS MED BR GALVESTON · PI ABBEY B BERENSON · 2023 to 2026
$2.7M
NIAMS NIH HHS K12 AR084228
6 · The paper itself

Abstract

End-stage Nipah virus (NiV) infection has been well studied; however, little is known about the development of NiV disease. Here, 12 African green monkeys (AGM) were exposed to NiV and examined over 5 days to investigate NiV pathogenesis. DC-SIGN-positive immature dendritic cells in tonsil and alveolar macrophages were identified at 3 days postinfection (DPI) as early targets, implicating a critical role in the spread of NiV to other tissues. By 5 DPI, NiV spread to endothelium and respiratory epithelium, while fibrin was noted in blood vessels and alveolar spaces. NiV antigen was not detected in cells of CNS tissues from any AGM 3-5 DPI, indicating that neuroinvasion is a late event. NiV elicited a biphasic host response characterized by early consumption of coagulation factors followed by induction of interferon-stimulated cytokines/chemokines and endothelial activation markers. RNA-seq identified a robust, complement-associated immune response in tonsil, versus a muted, interferon-associated response in lung.

Indexed as

TranscriptomicsVirology

Identifiers

PMID42181233
PMCPMC13196469

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.