ArticleFrontiers in endocrinology2026
Impact of trigger-day serum luteinizing hormone levels on embryo quality and pregnancy outcomes in overweight and obese women undergoing GnRH antagonist protocols: a retrospective cohort study.
Article in Frontiers in endocrinology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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1 citing paper in PubMed.
- Obesity alters the estrogen-induced luteinizing hormone surge in ovariectomized ewes†.Biology of reproduction · 2026Article
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7 authors.
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Abstract
Introduction: Luteinizing hormone (LH) is critical for follicular development and IVF pregnancy outcomes, but evidence linking trigger-day serum LH levels to IVF-ET outcomes in overweight patients is scarce. This study investigated the impact of trigger-day LH levels on IVF-ET outcomes in overweight and obese women (BMI ≥ 25 kg/m Methods: Clinical data from 1,135 overweight and obese women (first IVF/ICSI-ET cycle, July 2023-July 2024) were retrospectively analyzed. Patients were stratified into three groups based on the 25th (P25) and 75th (P75) percentiles of the trigger-day LH distribution: Group 1 (< P25, LH < 1.45 IU/L, n=272), Group 2 (P25-P75, 1.45 IU/L ≤ LH ≤ 4.19 IU/L, n=580), and Group 3 (> P75, LH > 4.19 IU/L, n=283). Ovarian response, embryo quality, and pregnancy outcomes were compared; binary logistic regression evaluated LH-pregnancy associations, with subgroup analyses by transfer type, PCOS status, and BMI category. Results: Group 1 had significantly more follicles ≥14 mm, retrieved/mature/fertilized oocytes, and high-quality embryos than Groups 2 and 3 (all Conclusion: Elevated trigger-day LH levels correlate with poorer ovarian response and embryo quality in overweight and obese women on GnRH antagonist protocol, but not with pregnancy outcomes, nor are they an independent predictor of IVF success.
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