ArticleFrontiers in endocrinology2026
Ancestry-informative regulatory variants at KCNB1 modulate adipogenesis and body mass index.
Article in Frontiers in endocrinology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Introduction: Obesity and related metabolic disorders represent a major global health burden, yet their genetic determinants remain incompletely characterized, particularly in non-European populations. We aimed to identify body mass index (BMI)-associated loci in an admixed Brazilian population and to functionally characterize ancestry-enriched variants contributing to obesity risk. Methods: We conducted a genome-wide association study (GWAS) of BMI in 1,079 admixed Brazilian individuals. Significant and suggestive loci were evaluated using integrative analysis, including epigenomic annotation and chromatin conformation data. Regulatory activity was assessed using allele-specific luciferase reporter assays and electrophoretic mobility shift assays. The functional role of the prioritized gene was examined using pharmacological inhibition in human preadipocytes and genetic deletion in mice. Results: We identified three BMI-associated loci reaching genome-wide significance (p ≤ 5 × 10 Discussion: Our findings identify KCNB1 as a regulator of adipogenesis and body composition and highlight the importance of studying admixed populations to uncover ancestry-specific genetic mechanisms underlying obesity.
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