ArticleFrontiers in endocrinology2026
Panx1 and P2X7R are associated with impaired skeletal health and delayed bone development in early onset of type 1 diabetes.
Article in Frontiers in endocrinology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors.
Funding
Abstract
Objectives: Type 1 diabetes (T1D) is a chronic autoimmune endocrine disorder that disrupts multiple physiological systems beyond glucose homeostasis. An underrecognized complication is impaired skeletal development during childhood and adolescence, a critical period for bone accrual. This study aimed to define the early-life effects of T1D on load-induced bone adaptation and to investigate the role of the osteocyte Panx1-P2X7R mechanosignaling complex in diabetes-associated skeletal deficits. Materials and methods: Akita (C57BL/6J-Ins2 Results: Load-induced periosteal bone formation in wild-type mice was accompanied by adaptive regulation of Panx1-P2X7R expression, whereas this response was disrupted in young adult T1D mice. Dysregulation emerged after one week of loading and was recapitulated in osteocytes exposed to OFSS Conclusion: Early-onset T1D impairs bone mechanoadaptation and is associated with dysregulated Panx1-P2X7R signaling and heightened inflammatory responses. Given the established roles of Panx1 and P2X7R in mechanosensitive signaling and inflammation, their disruption likely contributes to defective skeletal adaptation and inflammatory bone pathology, ultimately increasing skeletal fragility in T1D.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.