Evidence map›Paper›PMID 42181171›Full record

ArticleBioactive materials2026

Stage-specific biomimetic nanoparticles reprogram osteoblast-adipocyte equilibrium for targeted osteoporosis therapy.

Kehan Cai, Zhe Fan, Jun Tan, Wei Cai, Minghang Zhang, Haojie Tang, Jianzhong Xu, Han Lu, Wei He, Qian Xu and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Bioactive materials, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Kehan CaiDepartment of Orthopedic Surgery, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, 450052, China.
Zhe FanDepartment of Orthopedic Surgery, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, 450052, China.
Jun TanDepartment of Mini-invasive Spinal Surgery, The Third People's Hospital of Henan Province, Zhengzhou, 450000, China.
Wei CaiDepartment of Orthopedic Surgery, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, 450052, China.
Minghang ZhangDepartment of Orthopedic Surgery, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, 450052, China.
Haojie TangDepartment of Orthopedics, The Third People's Hospital of Henan Province, Zhengzhou, 450052, China.
Jianzhong XuDepartment of Orthopedic Surgery, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, 450052, China.
Han LuDepartment of Oral and Maxillofacial Surgery, The First Affiliated Hospital of Zhengzhou University, Zhengzhou University, Zhengzhou, 450052, China.
Wei HeDepartment of Oral and Maxillofacial Surgery, The First Affiliated Hospital of Zhengzhou University, Zhengzhou University, Zhengzhou, 450052, China.
Qian XuCollege of Life Science, Nanyang Normal University, Nanyang, 473061, China.
Yazhou ChenHenan Institute of Advanced Technology, Zhengzhou University, Zhengzhou, 450001, China.
Tao ChenDepartment of Orthopedic Surgery, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, 450052, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cell membrane-camouflaged nanoparticles have emerged as powerful tools for targeted drug delivery; however, current strategies typically utilize membranes from static cell states, overlooking the dynamic functional evolution that occurs during lineage commitment. Here, we established a stepwise osteogenic differentiation model for BMSCs and isolated cell membranes from distinct stages of this process to construct a series of cell membrane-camouflaged mesoporous silica nanoparticles (CM-MSNs). Proteomic profiling revealed stage-dependent remodeling of membrane protein composition, with early osteogenic (EO) stage membranes uniquely enriched in phosphatases and cadherins. Functional evaluations showed stage-dependent activity among CM-MSNs, and EO membrane-camouflaged nanoparticles (EO-MSNs) exhibited the strongest capacity to promote calcium deposition and enhance BMSC osteogenesis

Indexed as

Biomimetic nanoparticleBone formationOsteogenic differentiationOsteoporosisStepwise

Identifiers

PMID42181171
PMCPMC13196569

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.