Evidence map›Paper›PMID 42181154›Full record

ArticleJPRAS open2026

A premixed calcium hydroxylapatite/carboxymethylcellulose-hyaluronic acid hybrid filler for skin quality.

Andrea Lazzarotto, Stefania Guida, Jonathan Kadouch, Nabil Fakih-Gomez, Nicola Zerbinati, Luigi Colombo, Massimo Vitale, Mariana César Corrêa, Kyu-Ho Yi

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Article in JPRAS open, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Andrea LazzarottoDepartment of Maxillofacial and Plastic Surgery, University Hospital "ASST-Lariana" of Como, and Private Practice in Como, Milan and Udine, Italy.
Stefania GuidaSchool of Medicine, Dermatology Clinic, Vita-Salute San Raffaele University, IRCCS San Raffaele Scientific Institute, Milan, Italy.
Jonathan KadouchPractice for Aesthetic Dermatology, ReSculpt Clinic, Amsterdam, The Netherlands.
Nabil Fakih-GomezDepartment of Facial Plastic and Cranio-Maxillo-Facial Surgery, Fakih Hospital, Khaizaran, Lebanon.
Nicola ZerbinatiDepartment of Medicine and Surgery, University of Insubria, Varese, Italy.
Luigi ColomboDepartment of Maxillofacial and Plastic Surgery, University Hospital "ASST-Lariana" of Como, and Private Practice in Como, Milan and Udine, Italy.
Massimo VitalePrivate Practice, Bologna, Italy.
Mariana César CorrêaClinica Dermatologica Dra. Mariana Corrêa, São Paulo, Brazil.
Kyu-Ho YiDivision of Anatomy and Developmental Biology, Department of Oral Biology, Human Identification Research Institute, BK21 FOUR Project, Yonsei University College of Dentistry, Seoul, Republic of Korea.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Hybrid injectable approaches combining calcium hydroxylapatite/carboxymethylcellulose with hyaluronic acid gels may improve both facial contour and skin quality. Methods: We retrospectively reviewed 12 women treated with a premixed hybrid filler injected in the subdermal plane across the mid- and lower-face. Outcomes were assessed at baseline and 4 months using the Merz Aesthetic Scales for mid- and lower-face aging severity, the Lemperle Wrinkle Severity Scale (cheek wrinkles), and a 5-point Global Aesthetic Improvement Scale for patient-reported "skin glow." Results: All Merz domains and cheek wrinkle severity improved at 4 months (cheek wrinkles, Conclusions: In this retrospective case series, the premixed hybrid filler was well tolerated and was associated with improvement in mid- and lower-face aging severity and patient-perceived skin glow at 4 months. Level of evidence: IV.

Indexed as

Calcium hydroxylapatiteHyaluronic acidHybrid fillerSkin quality

Identifiers

PMID42181154
PMCPMC13196470

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.