Evidence map›Paper›PMID 42181108›Full record

ArticleCurrent research in toxicology2026

Aromatic aldehydes formed during heating of cinnamon-flavored e-liquids drive pro-inflammatory responses in human aortic smooth muscle cells.

Mariam Bitar, Jérémie Pourchez, Mohamad Sleiman, Laurent Bertoletti, Valérie Forest

Abstract read
In one paragraph

Article in Current research in toxicology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Mariam BitarMines Saint-Etienne, Univ Jean Monnet, INSERM, U 1059 Sainbiose, Centre CIS, F-42023 Saint-Etienne, France.
Jérémie PourchezMines Saint-Etienne, Univ Jean Monnet, INSERM, U 1059 Sainbiose, Centre CIS, F-42023 Saint-Etienne, France.
Mohamad SleimanUniversité Clermont Auvergne, Clermont Auvergne INP, CNRS, ICCF, F-63000 Clermont-Ferrand, France.
Laurent BertolettiService de Médecine Vasculaire et Thérapeutique, CHU de Saint-Etienne, Saint-Etienne, France.
Valérie ForestMines Saint-Etienne, Univ Jean Monnet, INSERM, U 1059 Sainbiose, Centre CIS, F-42023 Saint-Etienne, France.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Flavor additives can contribute to the biological effects of electronic cigarette (e-cigarette) aerosols, yet the mechanisms underlying flavor-related vascular toxicity remain poorly understood. We previously showed that exposure of human aortic smooth muscle cells (AoSMCs) to cinnamon-flavored e-cigarette aerosol induced a marked pro-inflammatory response that was amplified by heating. The present study aimed to identify thermal degradation products derived from cinnamon flavoring that may contribute to this effect. Aerosol condensates were generated from cinnamon-flavored e-liquids under controlled vaping conditions, and a chemical screening approach was used to identify degradation products. Benzaldehyde and phenylacetaldehyde were detected as specific to the heated cinnamon condensate and were subsequently selected for targeted

Indexed as

Aortic smooth muscle cellsCardiovascular effectCinnamonCytotoxicityE-cigarettesFlavorPro-inflammatory response

Identifiers

PMID42181108
PMCPMC13195778

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.