Evidence map›Paper›PMID 42181058›Full record

ArticleChemical science2026

A general strategy for high-efficiency live bacteria imaging and targeted phototherapy.

Xinci Wang, Lihao Ding, Jiang Liu, Jiahui Lv, Junjie Liu, Yu Yan, Xutong Li, Huan Shi, Hui Wang, Jiajia Wang and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Chemical science, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Xinci WangMOE Key Laboratory for Cellular Dynamics, Center for Advanced Interdisciplinary Science and Biomedicine of IHM, Hefei National Research Center for Interdisciplinary Sciences at the Microscale, Division of Life Sciences and Medicine, University of Science and Technology of China Hefei 230026 China linxue@ustc.edu.cn xinxingyang@ustc.edu.cn liusenquan1988@ustc.edu.cn.
Lihao DingMOE Key Laboratory for Cellular Dynamics, Center for Advanced Interdisciplinary Science and Biomedicine of IHM, Hefei National Research Center for Interdisciplinary Sciences at the Microscale, Division of Life Sciences and Medicine, University of Science and Technology of China Hefei 230026 China linxue@ustc.edu.cn xinxingyang@ustc.edu.cn liusenquan1988@ustc.edu.cn.ORCID https://orcid.org/0009-0008-4860-7828
Jiang LiuMOE Key Laboratory for Cellular Dynamics, Center for Advanced Interdisciplinary Science and Biomedicine of IHM, Hefei National Research Center for Interdisciplinary Sciences at the Microscale, Division of Life Sciences and Medicine, University of Science and Technology of China Hefei 230026 China linxue@ustc.edu.cn xinxingyang@ustc.edu.cn liusenquan1988@ustc.edu.cn.
Jiahui LvMOE Key Laboratory for Cellular Dynamics, Center for Advanced Interdisciplinary Science and Biomedicine of IHM, Hefei National Research Center for Interdisciplinary Sciences at the Microscale, Division of Life Sciences and Medicine, University of Science and Technology of China Hefei 230026 China linxue@ustc.edu.cn xinxingyang@ustc.edu.cn liusenquan1988@ustc.edu.cn.
Junjie LiuMOE Key Laboratory for Cellular Dynamics, Center for Advanced Interdisciplinary Science and Biomedicine of IHM, Hefei National Research Center for Interdisciplinary Sciences at the Microscale, Division of Life Sciences and Medicine, University of Science and Technology of China Hefei 230026 China linxue@ustc.edu.cn xinxingyang@ustc.edu.cn liusenquan1988@ustc.edu.cn.
Yu YanMOE Key Laboratory for Cellular Dynamics, Center for Advanced Interdisciplinary Science and Biomedicine of IHM, Hefei National Research Center for Interdisciplinary Sciences at the Microscale, Division of Life Sciences and Medicine, University of Science and Technology of China Hefei 230026 China linxue@ustc.edu.cn xinxingyang@ustc.edu.cn liusenquan1988@ustc.edu.cn.
Xutong LiDrug Discovery and Design Center, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences 555 Zuchongzhi Road Shanghai 201203 China.
Huan ShiMOE Key Laboratory for Cellular Dynamics, Center for Advanced Interdisciplinary Science and Biomedicine of IHM, Hefei National Research Center for Interdisciplinary Sciences at the Microscale, Division of Life Sciences and Medicine, University of Science and Technology of China Hefei 230026 China linxue@ustc.edu.cn xinxingyang@ustc.edu.cn liusenquan1988@ustc.edu.cn.
Hui WangMOE Key Laboratory for Cellular Dynamics, Center for Advanced Interdisciplinary Science and Biomedicine of IHM, Hefei National Research Center for Interdisciplinary Sciences at the Microscale, Division of Life Sciences and Medicine, University of Science and Technology of China Hefei 230026 China linxue@ustc.edu.cn xinxingyang@ustc.edu.cn liusenquan1988@ustc.edu.cn.
Jiajia WangMOE Key Laboratory for Cellular Dynamics, Center for Advanced Interdisciplinary Science and Biomedicine of IHM, Hefei National Research Center for Interdisciplinary Sciences at the Microscale, Division of Life Sciences and Medicine, University of Science and Technology of China Hefei 230026 China linxue@ustc.edu.cn xinxingyang@ustc.edu.cn liusenquan1988@ustc.edu.cn.
Senquan LiuMOE Key Laboratory for Cellular Dynamics, Center for Advanced Interdisciplinary Science and Biomedicine of IHM, Hefei National Research Center for Interdisciplinary Sciences at the Microscale, Division of Life Sciences and Medicine, University of Science and Technology of China Hefei 230026 China linxue@ustc.edu.cn xinxingyang@ustc.edu.cn liusenquan1988@ustc.edu.cn.
Duanhua CaoMedical Artificial Intelligence Innovation Center, Shanghai East Hospital, School of Medicine, School of Life Sciences and Technology, Tongji University Shanghai 200092 China caodh@tongji.edu.cn.
Xinxing YangMOE Key Laboratory for Cellular Dynamics, Center for Advanced Interdisciplinary Science and Biomedicine of IHM, Hefei National Research Center for Interdisciplinary Sciences at the Microscale, Division of Life Sciences and Medicine, University of Science and Technology of China Hefei 230026 China linxue@ustc.edu.cn xinxingyang@ustc.edu.cn liusenquan1988@ustc.edu.cn.
Lin XueMOE Key Laboratory for Cellular Dynamics, Center for Advanced Interdisciplinary Science and Biomedicine of IHM, Hefei National Research Center for Interdisciplinary Sciences at the Microscale, Division of Life Sciences and Medicine, University of Science and Technology of China Hefei 230026 China linxue@ustc.edu.cn xinxingyang@ustc.edu.cn liusenquan1988@ustc.edu.cn.ORCID https://orcid.org/0000-0002-4540-3386

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Bacterial peptidoglycan (PG) serves as a unique bacterial signature for imaging and therapeutic targeting, yet existing chemical probes require high concentrations and involve disruptive washing steps. Herein, we report a general strategy for designing high-performance PG probes by incorporating a fluorine-substituted benzenesulfonamide moiety. The structural modification promotes the binding of probes to PBPs and significantly improves their PG-incorporation efficiency. Using this approach, we developed a full-color probe palette spanning the visible spectrum, enabling wash-free imaging of live bacteria at low concentrations with outstanding signal-to-background ratios. Beyond imaging, this strategy further led to the creation of FluoEosinY, a PG-targeted photosensitizer that effectively inactivates antibiotic-resistant bacteria without inducing resistance. In a mouse model of methicillin-resistant

Identifiers

PMID42181058
PMCPMC13192278

What OpenQuestion holds

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LicenceCC BY-NC
Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.