From inactivation to intervention: X chromosome silencing in disease pathogenesis and emerging therapeutic strategies.

Yuan Fu, Xuling Tan, Lixia Qin, Chunyu Wang

Abstract readReview

In one paragraph

Review in Genes & diseases, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it

0cells of the map it votes in

2citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

Association Analysis of theGenes · 2026
Article
Genomic Instability and Clonal Hematopoiesis in the Deep-Space Environment: The Role of Sex-Chromosome Asymmetry and High-LET Radiation.Current stem cell reports · 2026
Article

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Yuan FuDepartment of Medical Genetics, The Second Xiangya Hospital of Central South University, Changsha, Hunan 41001, China.

Xuling TanDepartment of Medical Genetics, The Second Xiangya Hospital of Central South University, Changsha, Hunan 41001, China.

Lixia QinDepartment of Neurology, The Second Xiangya Hospital of Central South University, Changsha, Hunan 41001, China.

Chunyu WangDepartment of Medical Genetics, The Second Xiangya Hospital of Central South University, Changsha, Hunan 41001, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

X chromosome inactivation (XCI) is a crucial epigenetic mechanism that balances X-linked gene expression in females via random silencing of one X chromosome. Skewed XCI-non-random inactivation favoring one allele-impacts disease penetrance in X-linked disorders. In heterozygous females, phenotypic severity correlates with XCI skewing degree. Accurate XCI quantification is critical for predicting clinical variability and improving risk assessment in X-linked mutation carriers. The X inactivation-specific transcript (

Indexed as

Detection of X chromosome inactivationMechanismsThe inactive X chromosome reactivationTherapeutic strategiesX chromosome inactivation

Identifiers

PMID42180998

DOI10.1016/j.gendis.2025.101964

PMCPMC13196324

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.