ArticleTranslational cancer research2026
Comprehensive analysis and validation of the prognostic value of glycosylation- and mitophagy-related genes for head and neck squamous cell carcinoma.
Article in Translational cancer research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: The treatment of head and neck squamous cell carcinoma (HNSCC) is particularly difficult because of its aggressive nature, complex anatomical location, and high recurrence and metastasis rates. This study investigated the relationship between glycosylation and mitophagy-related genes in HNSCC. Methods: We used bioinformatics tools to analyze data from The Cancer Genome Atlas (TCGA) and Gene Expression Omnibus (GEO) databases. Specifically, we analyzed differentially expressed genes (DEGs), mutations, copy number variations (CNVs), Gene Ontology (GO) enrichment, and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment. Univariate and multivariate Cox regression analyses and Least Absolute Shrinkage and Selection Operator (LASSO) regression were performed to develop prognostic models, which were validated using GEO datasets. Results: We identified six key genes ( Conclusions: These findings highlight the diagnostic and prognostic potential of glycosylation- and mitophagy-related genes, laying the foundation for individualized HNSCC treatment.
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