Evidence map›Paper›PMID 42180960›Full record

ArticleTranslational cancer research2026

Association of primary lesion surgery and surgical modality with overall survival in patients with stage IV cutaneous melanoma: a population-based study.

Dun-Chang Mo, Long Chen, Yong-Jun Du, Peng-Hui Luo, Shang-Xiao Huang, Han-Lei Wang, Xiu-Juan Liang, Peng Lin, Jian-Feng Huang

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Article in Translational cancer research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

9 authors.

Dun-Chang Mo *Radiotherapy Department, The Second Nanning People's Hospital, The Third Affiliated Hospital of Guangxi Medical University, Nanning, China.
Long Chen *Otorhinolaryngology Head and Neck Surgery, The Second Nanning People's Hospital, The Third Affiliated Hospital of Guangxi Medical University, Nanning, China.
Yong-Jun Du *Department of Orthopaedics, The Second Nanning People's Hospital, The Third Affiliated Hospital of Guangxi Medical University, Nanning, China.
Peng-Hui LuoRadiotherapy Department, The Second Nanning People's Hospital, The Third Affiliated Hospital of Guangxi Medical University, Nanning, China.
Shang-Xiao HuangRadiotherapy Department, The Second Nanning People's Hospital, The Third Affiliated Hospital of Guangxi Medical University, Nanning, China.
Han-Lei WangRadiotherapy Department, The Second Nanning People's Hospital, The Third Affiliated Hospital of Guangxi Medical University, Nanning, China.
Xiu-Juan LiangRadiotherapy Department, The Second Nanning People's Hospital, The Third Affiliated Hospital of Guangxi Medical University, Nanning, China.
Peng LinRadiotherapy Department, The Second Nanning People's Hospital, The Third Affiliated Hospital of Guangxi Medical University, Nanning, China.
Jian-Feng HuangRadiotherapy Department, The Second Nanning People's Hospital, The Third Affiliated Hospital of Guangxi Medical University, Nanning, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Evidence regarding the impact of primary lesion surgery on survival in stage IV cutaneous melanoma (CM) patients is scarce. This study investigated the prognostic value of primary lesion resection for stage IV CM and survival differences across various surgical modalities. Methods: We extracted data on stage IV (M1a-c) CM patients diagnosed between 2010 and 2015 from the Surveillance, Epidemiology, and End Results (SEER) database. The cohort was divided into a surgical group (primary lesion resection) and a non-surgical control group, with overall survival (OS) as the primary endpoint. Propensity score matching (PSM) and Kaplan-Meier analysis were applied to compare clinical outcomes and identify relevant prognostic factors. Results: A total of 3,155 patients were included. After 1:2 PSM, 648 and 1,228 patients were assigned to the surgical and non-surgical groups, respectively. Patients who underwent primary lesion surgery had significantly longer OS than non-surgical patients both before and after PSM (all P<0.001). Subgroup analysis showed that gross excision or wide excision was associated with markedly longer OS than local tumor resection (P<0.001 and P=0.002, respectively). Gross excision had a numerically longer median OS than wide excision (25 Conclusions: Primary lesion surgery significantly improves OS in stage IV CM patients, and surgical modality correlates with survival outcomes. Gross excision may be the most effective approach, while wide excision may not provide additional survival benefits and may be unnecessary for this patient population in clinical practice.

Indexed as

overall survival (OS)primary lesion surgeryStage IV melanomasurgical modalitySurveillance, Epidemiology, and End Results database (SEER database)

Identifiers

PMID42180960
PMCPMC13190711

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