ArticleTranslational cancer research2026
Identification and analysis of endoplasmic reticulum stress-related genes in neuroblastoma and construction of a prognostic gene signature.
Article in Translational cancer research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Neuroblastoma (NB) is one of the most common malignant tumors in children. Despite intensive multimodal treatments, patients with high-risk NB still have a poor prognosis; therefore, early identification of high-risk patients based on reliable NB biomarkers is essential. Endoplasmic reticulum (ER) stress has been demonstrated to play a vital role in cancer biology; however, it is unclear whether ER stress-related genes are involved in NB and should be further explored as new potential diagnostic and prognostic targets. Methods: We searched publicly available datasets with the aim to identify ER stress-related genes with a role in NB and establish a predictive model using ER stress-related signatures based on clinical information. Results: Seventy-three ER stress-related genes were differentially expressed in NB cells; most of them were involved in biological processes such as intrinsic apoptotic signaling pathways and cellular responses to abiotic stimuli. Protein-protein interaction (PPI) analysis revealed hub genes, among which Conclusions: Among the 73 ER stress-related genes differentially expressed in NB, the 2 hub and 10 risk prediction-related genes could potentially serve as therapeutic biomarkers and prognostic indicators for patients with NB.
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