Evidence map›Paper›PMID 42180896›Full record

ArticleTranslational cancer research2026

Metaxins regulate cancer stem cell-like properties in H1299 cells.

Heabin Kim, Seung-Hyun Jung, Seonmi Jo, Jeong Moo Han, Jei Ha Lee

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Article in Translational cancer research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

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0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

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5 · Who and what money

Authors and funding

5 authors.

Heabin Kim *Department of Bio-material Research, National Marine Biodiversity Institute of Korea, Seocheon, Republic of Korea.
Seung-Hyun Jung *Department of Bio-material Research, National Marine Biodiversity Institute of Korea, Seocheon, Republic of Korea.
Seonmi JoDepartment of Biological Application and Technology, National Marine Biodiversity Institute of Korea, Seocheon, Republic of Korea.
Jeong Moo HanDepartment of Microbiology and Immunology, College of Medicine, Seoul National University, Seoul, Republic of Korea.
Jei Ha LeeDepartment of Bio-material Research, National Marine Biodiversity Institute of Korea, Seocheon, Republic of Korea.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Lung cancer remains the leading cause of cancer-related mortality and has the highest rates of recurrence and resistance to therapy. Metaxins (MTX1 and MTX2) are outer mitochondrial membrane proteins involved in protein trafficking. In this study, we aimed to elucidate the roles of metaxins in lung cancer. Methods: Lung cancer cells (H1299) were transfected with siRNA targeting Results: We observed increased methylation levels of the Conclusions: To the best of our knowledge, this is the first study to evidence the involvement of metaxins in CSC maintenance in lung cancer. The findings of this study indicate that MTX1 and MTX2 are potential therapeutic targets for overcoming EMT and stemness in patients with lung cancer.

Indexed as

epithelial-mesenchymal transition (EMT)lung cancerMetaxinstem cell

Identifiers

PMID42180896
PMCPMC13190770

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.