ArticleAmerican journal of cardiovascular disease2026
Association between inflammatory diseases and connective tissue disorders with atrial fibrillation/flutter.
Article in American journal of cardiovascular disease, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundThe role of inflammatory disease in the occurrence of atrial fibrillation/flutter (AF/AFL) is not well studied.
objectiveThe goal of this study was to evaluate any association between inflammatory and autoimmune disorders with the occurrences of AF/AFL using a large database.
methodsUsing the Nationwide Inpatient Sample (NIS) database and ICD-10 codes for AF/AFL and several inflammatory diseases for the years 2016-2020, we evaluated the above association.
resultsA total of 23,037,013 patients were identified with a diagnosis of AF/AFL. The following diseases were independently associated with the presence of AF/AFL despite adjustment for age, demographics, and traditional risk factors: rheumatoid arthritis: OR: 1.05, CI 1.04-1.06, P<0.001, systemic sclerosis OR: 1.31, CI 1.26-1.36, P<0.001, systemic connective tissue disorders: OR: 1.07, CI 1.05-1.08, P<0.001, antiphospholipid syndrome: OR: 1.36, CI: 1.31-1.42, P<001, systemic lupus erythematosus: OR: 1.15, CI: 1.13-1.17, P<0.001 and Raynaud's syndrome: OR: 1.1, CI: 1.07-1.13, P<0.001. Ankylosing spondylitis was not found to be associated with AF/AFL.
conclusionUsing a large inpatient database, we found that some common inflammatory diseases and connective tissue disorders are independently associated with the presence of AF/AFL. Our findings are hypothesis-generating, requiring confirmation in prospective controlled trials.
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