ReviewFrontiers in medicine2026
Intraosseous therapy: harnessing the potential of tissue regeneration and repair.
Review in Frontiers in medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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0 citing papers in PubMed.
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Authors and funding
2 authors.
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Abstract
Tissue regeneration and repair remain significant challenges in various medical fields, particularly in the context of musculoskeletal conditions. Intraosseous therapy has emerged as a promising approach, harnessing the body's intrinsic regenerative potential to promote bone and tissue regeneration. This review provides a comprehensive overview of intraosseous therapy, including its principles, strategies, and clinical applications. The bone biology and regeneration processes are discussed, along with the roles of cellular components such as osteoblasts, osteoclasts, osteocytes, and mesenchymal stem cells. Intraosseous therapy encompasses various approaches, including Bone marrow aspirate concentrate (BMAC), platelet-rich plasma (PRP), stem cell-based therapies (mesenchymal stem cells, induced pluripotent stem cells, and other sources), biomaterials and scaffolds, and growth factors. The clinical applications of intraosseous therapy span bone fracture repair and non-union, spinal fusion, craniofacial and maxillofacial reconstruction, osteonecrosis and avascular necrosis, and osteoporosis and bone defects. While intraosseous therapy holds significant promise, challenges related to regulatory and ethical considerations, standardization and quality control, clinical translation and commercial viability, and future research directions in personalized medicine, advanced biomaterials, combination therapies, and
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