ReviewFrontiers in medicine2026
Maintenance and disruption of mucous barrier homeostasis: the critical role of MUC5AC/MUC5B balance in airway diseases.
Review in Frontiers in medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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4 authors.
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Abstract
Airway diseases pose a major challenge to global health, with excessive mucus secretion being one of their common pathological cores. As the primary functional components of the airway mucus gel, MUC5AC and MUC5B jointly maintain mucus barrier function under physiological conditions. However, during disease progression, dysregulation of these two mucins becomes a key factor driving disease advancement. Understanding the expression patterns and regulatory mechanisms of MUC5AC and MUC5B in disease states is crucial for elucidating related pathological mechanisms. This review systematically summarizes relevant studies to explore the dynamic changes of these two mucins across multiple airway diseases, aiming to provide new perspectives and potential targets for precision diagnosis and treatment of airway diseases.
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