Evidence map›Paper›PMID 42180745›Full record

ArticleFrontiers in medicine2026

Photodynamic technology for delineating surgical margins in recurrent extramammary Paget's disease: a case report.

Xuan Guo, Haixia Wang, Xueqing Wang, Nan Cao, Zhiqiang Zhang, Shengli Chen, Guangliang Zhang

Abstract readCase Reports
In one paragraph

Article in Frontiers in medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Xuan Guo *Dermatology Hospital of Shandong First Medical University, Jinan, Shandong, China.
Haixia Wang *Dermatology Hospital of Shandong First Medical University, Jinan, Shandong, China.
Xueqing WangDermatology Hospital of Shandong First Medical University, Jinan, Shandong, China.
Nan CaoDermatology Hospital of Shandong First Medical University, Jinan, Shandong, China.
Zhiqiang ZhangDermatology Hospital of Shandong First Medical University, Jinan, Shandong, China.
Shengli ChenDermatology Hospital of Shandong First Medical University, Jinan, Shandong, China.
Guangliang ZhangDermatology Hospital of Shandong First Medical University, Jinan, Shandong, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Extramammary Paget's disease (EMPD) is a rare cutaneous malignancy characterized by a high propensity for recurrence and metastasis. EMPD typically presents as slowly progressive, ill-defined erythematous plaques, which are often misdiagnosed as inflammatory dermatoses, leading to delayed diagnosis. Surgical excision remains the standard treatment for EMPD; however, due to ambiguous lesion borders, positive surgical margins frequently occur, resulting in a high local recurrence rate. In this study, we aimed to evaluate the clinical efficacy and safety of photodynamic diagnosis (PDD) in assisting surgical margin delineation for cutaneous tumors. Methods: A retrospective analysis was conducted on a patient with histologically confirmed scrotal EMPD. Despite multiple prior Mohs procedures and wide excisions, the disease relapsed. Ultimately, fluorescence-guided photodynamic technology was adopted to precisely demarcate tumor boundaries, followed by surgical excision according to the delineated margins. Results: Postoperative histopathological examination confirmed clear surgical margins and complete tumor resection. The patient is under continuous follow-up. Conclusion: Photodynamic technology facilitates accurate tumor margin delineation, guidessurgical resection extent, reduces recurrence risk, and improves patient comfort.

Indexed as

cutaneous tumordermatologic surgeryextramammary Paget’s diseaseMohsphotodynamic diagnosis (PDD)

Identifiers

PMID42180745
PMCPMC13194420

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