Evidence map›Paper›PMID 42180553›Full record

ArticleActa pharmaceutica Sinica. B2026

CD74 deficiency protects against doxorubicin cardiotoxicity through RRM2-mediated regulation of ferroptosis.

Miyesaier Abudureyimu, Guizhen Wang, Xing Qin, Peizhi Miao, Jie Qi, Richard Bucala, Rong Chen, Junbo Ge, Yingmei Zhang, Xuanming Luo and 1 more

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In one paragraph

Article in Acta pharmaceutica Sinica. B, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Miyesaier AbudureyimuCardiovascular Department, Shanghai Xuhui Central Hospital, Fudan University, Shanghai 200031, China.
Guizhen WangDepartment of Emergency, Shanghai Tenth People's Hospital, School of Medicine Tongji University, Shanghai 200072, China.
Xing QinDepartment of Cardiology, Xijing Hospital, Air Force Medical University, Xi'an 710032, China.
Peizhi MiaoCardiovascular Department, Shanghai Xuhui Central Hospital, Fudan University, Shanghai 200031, China.
Jie QiSchool of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou 325035, China.
Richard BucalaDepartment of Medicine, Yale School of Medicine, New Haven, CT 06520, USA.
Rong ChenDepartment of Pharmacy, The First Affiliated Hospital of Soochow University, Suzhou 215006, China.
Junbo GeDepartment of Cardiology, Zhongshan Hospital, Fudan University, Shanghai Institute of Cardiovascular Diseases, Shanghai 200032, China.
Yingmei ZhangDepartment of Cardiology, Zhongshan Hospital, Fudan University, Shanghai Institute of Cardiovascular Diseases, Shanghai 200032, China.
Xuanming LuoDepartment of General Surgery, Shanghai Xuhui Central Hospital, Fudan University, Shanghai 200031, China.
Jun RenDepartment of Cardiology, Zhongshan Hospital, Fudan University, Shanghai Institute of Cardiovascular Diseases, Shanghai 200032, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Doxorubicin (DOX)-induced cardiotoxicity (DIC) is a major health threat that limits its clinical application. While mitochondrial dysfunction, oxidative stress and ferroptosis are implicated in DIC pathology, the precise mechanism remains elusive. This study evaluated the role of cluster of differentiation 74 (CD74), an immunoregulatory protein, in DIC. Our findings revealed elevated CD74 levels in blood samples from DOX-exposed patients and DOX-challenged mouse hearts. CD74 deletion mitigated DOX-indued cardiac remodeling, contractile anomaly, mitochondrial abnormalities, apoptosis, and ferroptosis. Mechanistically, CD74 bound to DNA synthesis molecule ribonucleotide reductase M2 (RRM2), redistributing it from cytoplasm to plasma membrane, impairing DOX-induced repair and exacerbating mitochondrial injury, apoptosis, and ferroptosis

Indexed as

AmifostineCardiotoxicityCD74DoxorubicinFerroptosisMitochondrial integrityOxidative stress

Identifiers

PMID42180553
PMCPMC13198236

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.