Evidence map›Paper›PMID 42180549›Full record

ArticleActa pharmaceutica Sinica. B2026

Trojan horse-inspired smart single-atom nanozyme delivery system for synergistic therapy of inflammatory bowel disease.

Tianliang Li, Zhijie Wang, Xin Chang, Tianhao Su, Zhaoming Wang, Lixing Lin, Zeyu Li, Xiang Wang, Yingying Chen, Zhenzhen Li and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Acta pharmaceutica Sinica. B, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Tianliang LiMaterials Genome Institute, Shanghai Engineering Research Center for Integrated Circuits and Advanced Display Materials, and Shanghai Engineering Research Center of Organ Repair, Shanghai University, Shanghai 200444, China.
Zhijie WangDepartment of Gastroenterology, Affiliated Hangzhou First People's Hospital, School of Medicine, Westlake University, Hangzhou 310006, China.
Xin ChangDepartment of Gastroenterology and Changhai Clinical Research Unit, Changhai Hospital, and National Key Laboratory of Immunity and Inflammation, Naval Medical University, Shanghai 200433, China.
Tianhao SuMaterials Genome Institute, Shanghai Engineering Research Center for Integrated Circuits and Advanced Display Materials, and Shanghai Engineering Research Center of Organ Repair, Shanghai University, Shanghai 200444, China.
Zhaoming WangDepartment of Colorectal Surgery, Changhai Hospital, and National Key Laboratory of Immunity and Inflammation, Naval Medical University, Shanghai 200433, China.
Lixing LinMaterials Genome Institute, Shanghai Engineering Research Center for Integrated Circuits and Advanced Display Materials, and Shanghai Engineering Research Center of Organ Repair, Shanghai University, Shanghai 200444, China.
Zeyu LiMaterials Genome Institute, Shanghai Engineering Research Center for Integrated Circuits and Advanced Display Materials, and Shanghai Engineering Research Center of Organ Repair, Shanghai University, Shanghai 200444, China.
Xiang WangKey Laboratory of Integrated Oncology and Intelligent Medicine of Zhejiang Province, Affiliated Hangzhou First People's Hospital, School of Medicine, Westlake University, Hangzhou 310006, China.
Yingying ChenMaterials Genome Institute, Shanghai Engineering Research Center for Integrated Circuits and Advanced Display Materials, and Shanghai Engineering Research Center of Organ Repair, Shanghai University, Shanghai 200444, China.
Zhenzhen LiMaterials Genome Institute, Shanghai Engineering Research Center for Integrated Circuits and Advanced Display Materials, and Shanghai Engineering Research Center of Organ Repair, Shanghai University, Shanghai 200444, China.
Jianfeng YangDepartment of Gastroenterology, Affiliated Hangzhou First People's Hospital, School of Medicine, Westlake University, Hangzhou 310006, China.
Yu BaiDepartment of Gastroenterology and Changhai Clinical Research Unit, Changhai Hospital, and National Key Laboratory of Immunity and Inflammation, Naval Medical University, Shanghai 200433, China.
Zixuan HeDepartment of Gastroenterology and Changhai Clinical Research Unit, Changhai Hospital, and National Key Laboratory of Immunity and Inflammation, Naval Medical University, Shanghai 200433, China.
Lingyan FengMaterials Genome Institute, Shanghai Engineering Research Center for Integrated Circuits and Advanced Display Materials, and Shanghai Engineering Research Center of Organ Repair, Shanghai University, Shanghai 200444, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Systemic administration for the clinical management of inflammatory bowel disease (IBD) often leads to various side effects and toxicities, primarily due to broad therapeutic exposure of non-target tissues. Herein, a smart single-atom nanozyme (SAzymes) delivery system (Fe-SA/Cur@HAD, FCH) is constructed through coordinating iron-doped SAzymes (Fe-SA) with curcumin (Cur) for IBD synergistic therapy. Inspired by Trojan horse, FCH efficiently responds to the IBD pathological microenvironment and realizes targeted delivery

Indexed as

Cascade reactionCurcuminDelivery systemInflammatory bowel diseaseNanozymeOrallyOxidative stressSingle atom

Identifiers

PMID42180549
PMCPMC13198350

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.