ArticleRegenerative therapy2026
Effects of stem cells derived from the apical papilla (SCAP) on dental pulp outcomes: the influence of docosahexaenoic acid (DHA).
Article in Regenerative therapy, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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6 authors.
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Abstract
Introduction: This study investigated the effects of conditioned medium from stem cells of the apical papilla (CM-SCAP) modulated by the pro-resolution mediator docosahexaenoic acid (DHA), with or without a hydroxyapatite/tricalcium phosphate (HATCP) scaffold, on dental pulp-related outcomes. Methods: Human SCAP were isolated from extracted third molars, cultured, and exposed to DHA (1 μM) and/or HATCP. We assessed the effects of CM-SCAP, with or without treatments, on the viability, morphology, and mineralization rates of rat incisor dental pulp cells Results: CM from untreated SCAP reduced pulp cell viability only at high seeding density (10,000 cells/well), with no effect at lower densities. CM from DHA-treated SCAP increased pulp cell area and induced a spindle-to-cuboidal morphological change. After 21 days in osteogenic conditions, CM-SCAP combined with DHA and/or HATCP did not alter alkaline phosphatase activity but slightly increased mineral deposition, independent of HATCP. All treatments significantly reduced radiographic periapical lesions, while DHA-pretreated CM-SCAP decreased histological scores without affecting bacterial load. Conclusions: These findings suggest that DHA-modulated CM-SCAP, particularly in combination with HATCP, holds promise for dental pulp regeneration.
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