ArticleJournal of oral microbiology2026
CRISPR spacer profiling and prophage mining reveal diverse bacteriophages associated with
Xiaolin Chen, Mingrui Zhang, Liuchang Yang, Yuxing Chen, Yaqi Chi, Yiran Zhao, Zhe Ma, Yongliang Li, Xiaoyan Wang
Abstract read
In one paragraphArticle in Journal of oral microbiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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5 · Who and what moneyAuthors and funding
9 authors.
Xiaolin ChenDepartment of Cariology and Endodontology, Peking University School and Hospital of Stomatology & National Center for Stomatology & National Clinical Research Center for Oral Diseases & National Engineering Research Center of Oral Biomaterials and Digital Medical Devices & Beijing Key Laboratory of Digital Stomatology & NHC Key Laboratory of Digital Stomatology & NMPA Key Laboratory for Dental Materials, Beijing, People's Republic of China.
Mingrui ZhangSchool of Stomatology, Hebei Medical University, Shijiazhuang, People's Republic of China.
Liuchang YangDepartment of Cariology and Endodontology, Peking University School and Hospital of Stomatology & National Center for Stomatology & National Clinical Research Center for Oral Diseases & National Engineering Research Center of Oral Biomaterials and Digital Medical Devices & Beijing Key Laboratory of Digital Stomatology & NHC Key Laboratory of Digital Stomatology & NMPA Key Laboratory for Dental Materials, Beijing, People's Republic of China.
Yuxing ChenDepartment of Cariology and Endodontology, Peking University School and Hospital of Stomatology & National Center for Stomatology & National Clinical Research Center for Oral Diseases & National Engineering Research Center of Oral Biomaterials and Digital Medical Devices & Beijing Key Laboratory of Digital Stomatology & NHC Key Laboratory of Digital Stomatology & NMPA Key Laboratory for Dental Materials, Beijing, People's Republic of China.
Yaqi ChiDepartment of Cariology and Endodontology, Peking University School and Hospital of Stomatology & National Center for Stomatology & National Clinical Research Center for Oral Diseases & National Engineering Research Center of Oral Biomaterials and Digital Medical Devices & Beijing Key Laboratory of Digital Stomatology & NHC Key Laboratory of Digital Stomatology & NMPA Key Laboratory for Dental Materials, Beijing, People's Republic of China.
Yiran ZhaoDepartment of Cariology and Endodontology, Peking University School and Hospital of Stomatology & National Center for Stomatology & National Clinical Research Center for Oral Diseases & National Engineering Research Center of Oral Biomaterials and Digital Medical Devices & Beijing Key Laboratory of Digital Stomatology & NHC Key Laboratory of Digital Stomatology & NMPA Key Laboratory for Dental Materials, Beijing, People's Republic of China.
Zhe MaSchool of Stomatology, Hebei Medical University, Shijiazhuang, People's Republic of China.
Yongliang LiDepartment of Cariology and Endodontology, Peking University School and Hospital of Stomatology & National Center for Stomatology & National Clinical Research Center for Oral Diseases & National Engineering Research Center of Oral Biomaterials and Digital Medical Devices & Beijing Key Laboratory of Digital Stomatology & NHC Key Laboratory of Digital Stomatology & NMPA Key Laboratory for Dental Materials, Beijing, People's Republic of China.ORCID https://orcid.org/0000-0001-5016-2778 Xiaoyan WangDepartment of Cariology and Endodontology, Peking University School and Hospital of Stomatology & National Center for Stomatology & National Clinical Research Center for Oral Diseases & National Engineering Research Center of Oral Biomaterials and Digital Medical Devices & Beijing Key Laboratory of Digital Stomatology & NHC Key Laboratory of Digital Stomatology & NMPA Key Laboratory for Dental Materials, Beijing, People's Republic of China.ORCID https://orcid.org/0000-0002-8763-289X Funding
No grant is acknowledged in the PubMed record.
6 · The paper itselfAbstract
Background: Streptococcus mutans is a key cariogenic bacterium. Current antimicrobials lack species specificity, while phage-based approaches remain experimental and require more Objective: To profile the diversity of Materials and methods: We compiled 944 publicly available Results: CRISPR systems were detected in 548/735 strains, yielding 14,263 spacers, 1,864 phage-targeting spacers mapped to 110 viral genomes, including 41 cultured isolates, 51 metagenome-assembled phages, and 18 uncultured viral genomes. The most frequently targeted cultured phage was phiKSM96, whereas metagenome-assembled Conclusion: These findings reveal a vast, uncultivated phage repertoire targeting
Indexed as
comparative genomicsCRISPR-Casdental cariesphage therapyprophagespacer targetingStreptococcus mutans
Identifiers
PMID42180316
PMCPMC13195714
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