Evidence map›Paper›PMID 42180281›Full record

ArticleJournal of advanced veterinary and animal research2026

Microalgae as a prospective antibiotic replacement therapy for induced endometritis in rats through regulating inflammatory cytokines.

Emtenan M Hanafi, Moetazza M Alshafei, Heba H Hozyen, Manal M Ramadan, Yasser H A Saber, Reda M S Korany, Reda M S Korany, Enas N Danial, Seham S Kasem, Naglaa A Ali and 2 more

Abstract read
In one paragraph

Article in Journal of advanced veterinary and animal research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Emtenan M HanafiDepartment of Animal Reproduction and AI, NRC, Dokki, Giza, Egypt.ORCID https://orcid.org/0000-0001-8898-6385
Moetazza M AlshafeiDepartment of Nutrition and Food Sciences, NRC, Dokki, Giza, Egypt.ORCID https://orcid.org/0000-0002-7372-200X
Heba H HozyenDepartment of Animal Reproduction and AI, NRC, Dokki, Giza, Egypt.ORCID https://orcid.org/0000-0002-8979-7612
Manal M RamadanDepartment of Chemistry of Flavor of Aromatic Plants, NRC, Dokki, Giza, Egypt.ORCID https://orcid.org/0000-0001-9908-5363
Yasser H A SaberDepartment of Animal Reproduction and AI, NRC, Dokki, Giza, Egypt.ORCID https://orcid.org/0000-0002-3002-7621
Reda M S KoranyDepartment of Pathology, Faculty of Veterinary Medicine, Cairo Univ, Giza, Egypt.ORCID https://orcid.org/0000-0002-2169-0317
Reda M S KoranyDepartment of Pathology, Faculty of Veterinary Medicine, Cairo Univ, Giza, Egypt.ORCID https://orcid.org/0000-0002-2169-0317
Enas N DanialDepartment of Chemistry of Natural and Microbial Products, NRC, Dokki, Giza, Egypt.ORCID https://orcid.org/0000-0002-6225-5100
Seham S KasemDepartment of Nutrition and Food Sciences, NRC, Dokki, Giza, Egypt.ORCID https://orcid.org/0000-0001-7333-5424
Naglaa A AliDepartment of Hormones, Medical and Clinical Studies Institute, NRC, Dokki, Giza, Egypt.ORCID https://orcid.org/0000-0001-5248-0665
Safaa H MohamedDepartment of Hormones, Medical and Clinical Studies Institute, NRC, Dokki, Giza, Egypt.ORCID https://orcid.org/0000-0002-1726-8738
Ghada H ElsayedDepartment of Hormones, Medical and Clinical Studies Institute, NRC, Dokki, Giza, Egypt.ORCID https://orcid.org/0000-0002-5505-217X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objectives: The purpose of this study was to monitor the antimicrobial role of Materials and Methods: After preparation of encapsulated flavoured microalgae, they were mixed into the animal diet at 1%. The antioxidant and antimicrobial activity of the algae was studied. 45 adult female rats were classified into 3 groups (G1, G2, and G3) where each group had 15 rats in number. The first group ate a control basal diet (CD), the second group received CD mixed with SP, and G3 received CD mixed with CV. After 20 days of supplementation, animals were infected with an intravaginal injection of a pathogenic strain of Results: SP and CV exhibit strong antioxidant, antimicrobial, and anti-inflammatory effects, and a high rate of uterine clearance, as indicated by downregulation of target cytokine genes used as indicators of the inflammatory process. Significant elevation in plasma cytokines ( Conclusions: The study paved the way for the prospective pharmaceutical use of microalgae as an antibiotic replacement therapy or for the extraction of active antimicrobial components.

Indexed as

Chlorella vulgarisEndometritisimmunohistochemistryinflammatory cytokine genesSpirulina platensis

Identifiers

PMID42180281
PMCPMC13197678

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.