Evidence map›Paper›PMID 42180251›Full record

ArticleFrontiers in cellular and infection microbiology2026

Proton pump inhibitor exposure modulates functional and transcriptional responses in

Romen Singh Naorem, Kalpajit Dutta, Sudipta Sankar Bora, Anju Barhai Teli

Abstract read
In one paragraph

Article in Frontiers in cellular and infection microbiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Romen Singh NaoremMultidisciplinary Research Unit, Jorhat Medical College and Hospital, Jorhat, India.
Kalpajit DuttaMultidisciplinary Research Unit, Jorhat Medical College and Hospital, Jorhat, India.
Sudipta Sankar BoraMultidisciplinary Research Unit, Jorhat Medical College and Hospital, Jorhat, India.
Anju Barhai TeliMultidisciplinary Research Unit, Jorhat Medical College and Hospital, Jorhat, India.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Proton pump inhibitors (PPIs) are among the most widely prescribed medications for gastric acid-related disorders. However, their effect on the gut microbiota remains incompletely understood, despite emerging evidence suggesting potential long-term alterations in microbial composition and reductions in beneficial taxa. In this study,

Indexed as

Gene Expression Regulation, BacterialLactobacillus acidophilusProton Pump InhibitorsTranscription, GeneticAnti-Bacterial AgentsBacterial ProteinsComputational BiologyGene Expression ProfilingMicrobial Sensitivity TestsMolecular Docking SimulationMolecular Dynamics SimulationAnti-Bacterial AgentsBacterial ProteinsProton Pump Inhibitorsdrug targetsLactobacillus acidophilusmolecular dynamicsoff-targetsproton pump inhibitorstranscriptional repression

Identifiers

PMID42180251
PMCPMC13194612

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.