ReviewFrontiers in cellular and infection microbiology2026
Oxford Nanopore Sequencing in pediatric emergency infectious diseases: from rapid diagnosis to precision medicine.
Review in Frontiers in cellular and infection microbiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
1 citing paper in PubMed.
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Pediatric emergency infectious diseases necessitate rapid and accurate etiologic diagnosis to inform timely, life-saving interventions. However, conventional diagnostic approaches are often hindered by prolonged turnaround times and limited capability in detecting diverse pathogens. Oxford Nanopore Technologies (ONT) sequencing, a fourth-generation, real-time genomic platform, offers a transformative solution. With unique features such as ultra-long read lengths, real-time data streaming, and portability, ONT enables comprehensive microbial characterization directly at the point of care, even from low-biomass clinical specimens. This review outlines the fundamental principles of ONT sequencing and recent advances in protocol optimization for challenging pediatric samples. We highlight its groundbreaking applications in acute respiratory, bloodstream, and central nervous system infections, demonstrating its capacity to simultaneously deliver pathogen identification, antimicrobial resistance profiling, and strain typing. Moreover, ONT facilitates novel insights into host-pathogen interactions through integrated genomic and transcriptomic analyzes. We also address current challenges, including bioinformatics complexity and analytical standardization, and propose pathways toward integration within a precision infectious disease framework. Beyond diagnostics, ONT is emerging as a powerful tool to advance infection biology and improve clinical outcomes in children.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.