ArticleFrontiers in neurology
Diagnostic value of thromboelastography combined with conventional coagulation tests for lower extremity deep vein thrombosis after cerebrovascular surgery: a retrospective cohort study.
Article in Frontiers in neurology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Objective: To investigate the diagnostic efficacy of thromboelastography (TEG) combined with conventional coagulation tests for lower extremity deep vein thrombosis (DVT) following cerebrovascular surgery. Methods: This single-center retrospective cohort study evaluated 187 patients who underwent open cerebrovascular surgery at Nanjing Brain Hospital between January 2024 and February 2026. TEG parameters (R, K, Angle, MA) and conventional coagulation indices (PT, APTT, FIB, D-dimer) were extracted preoperatively and on postoperative day 3. Bilateral lower extremity ultrasonography performed within 7 days postoperatively served as the gold standard for DVT diagnosis. Multivariable logistic regression was utilized to identify independent predictors, and receiver operating characteristic (ROC) curves were analyzed to assess diagnostic performance. Results: The postoperative DVT incidence was 46.5% (87/187). Patients in the DVT group were significantly older (median: 67.0 vs. 60.5 years, Conclusion: The combination of TEG and conventional coagulation tests demonstrates substantial value for the early auxiliary diagnosis of DVT following cerebrovascular surgery. Angle, D-dimer, and hypertension are independent associated factors in this population. The combined diagnostic model provides excellent overall discrimination and high specificity, effectively reducing false positives in clinical screening and offering robust evidence for perioperative targeted anticoagulation management.
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