ArticleFrontiers in neurology
Retinal layer reflectivity and thickness as OCT biomarkers for diagnosis and imaging-based stratification relative to the 4.5-h window in acute central retinal artery occlusion.
Article in Frontiers in neurology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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Who cites it
1 citing paper in PubMed.
- Impact of an eye-stroke protocol with non-mydriatic ocular imaging in an emergency department.Frontiers in neurology · 2026Article
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9 authors.
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No grant is acknowledged in the PubMed record.
Abstract
Purpose: To quantify optical coherence tomography (OCT)-derived retinal layer reflectivity and retinal thickness changes in acute central retinal artery occlusion (CRAO) for rapid diagnosis and stratification of ischemic tissue state, referenced to the clinically relevant 4.5-h window for reperfusion therapies. Methods: This retrospective multicenter study included 39 patients with unilateral acute non-arteritic CRAO imaged by OCT within 48 h of reliably reported symptom onset. Five horizontal macular B-scans per eye [central (foveal), two superior, two inferior] were analyzed. Inner retinal layers (IRL) and outer retinal layers (ORL) were manually segmented. Mean grayscale reflectivity was extracted from predefined regions of interest and summarized as the within-eye IRL/ORL reflectivity ratio. Retinal thickness was obtained from Early Treatment Diabetic Retinopathy Study (ETDRS) sectors; relative retinal thickness increase (RRTI) was defined as CRAO-eye thickness divided by fellow-eye thickness. Diagnostic performance (CRAO vs. fellow eye) and classification relative to the 4.5-h reference (< 4.5 vs. ≥ 4.5 h) were assessed using receiver operating characteristic (ROC) analyses and non-parametric testing. Results: The within-eye IRL/ORL reflectivity ratio reliably distinguished CRAO-affected eyes from fellow eyes across all macular scan locations (AUC = 0.98-0.99; Conclusion: Quantitative OCT biomarkers based on within-eye reflectivity redistribution and retinal edema enable accurate diagnosis of acute CRAO and provide objective imaging-based information on ischemic tissue state, referenced to the 4.5-h therapeutic window. These rapidly obtainable measures may support acute stroke triage and telemedical workflows. Prospective validation, particularly in unknown-onset CRAO, is warranted before clinical implementation.
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