ArticleACS environmental Au2026
Ferroptosis and Wnt/β-Catenin Signaling Triggered by Environmentally Relevant Nanoscale Polypropylene Plastics in Human Intestinal Models.
Article in ACS environmental Au, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
9 authors.
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Abstract
Nanoplastics generated through environmental weathering may disrupt epithelial barrier integrity by promoting oxidative damage and inflammation, yet most studies rely solely on pristine synthetic particles that lack surface chemistries representative of real-world aged plastics. Here, we investigated the biological effects of environmentally relevant nanoscale polypropylene reference material (NPPP-1) produced by laser ablation and evaluated its material-specific responses under matched particle-number exposure conditions, in comparison with pristine and ultraviolet-aged synthetic polypropylene in human small intestinal organoids (HSIOs) and human intestinal epithelial cells. NPPP-1 induced oxidative stress, with elevated reactive oxygen species (ROS), lipid peroxidation, and DNA oxidation, accompanied by upregulation of genes and proteins associated with inflammation, ROS, and cell death pathways. Functional assays revealed concomitant activation of ferroptosis, apoptosis, and pyroptosis. Ferroptosis was the primary driver of cell death, as evidenced by partial rescue of viability mediated by ferroptosis inhibitor ferrostatin-1. In HSIOs, NPPP-1 triggered nuclear translocation and accumulation of β-catenin and upregulated the Wnt target gene
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