ArticleFrontiers in oncology2026
Rectal malignant peripheral nerve sheath tumor with extremely high Ki-67 index (80%) and concomitant meningioma history: a case report.
Article in Frontiers in oncology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Malignant peripheral nerve sheath tumor (MPNST) is an extremely rare and highly aggressive sarcoma with a generally poor prognosis. We report a case of a 68-year-old female with a 10-year history of meningioma resection (sporadic MPNST, no NF1 family history or clinical manifestations) who presented with anal pain without typical rectal cancer symptoms. Pelvic MRI showed a lesion in the lower rectum, presenting a "target sign" on T2WI and high signal on DWI. Postoperative pathological and immunohistochemical findings confirmed MPNST (S-100 (+), SOX-10 (+), H3K27me3 (partial loss), Ki-67 (80%)). The patient underwent laparoscopic abdominoperineal resection (APR) following the total mesorectal excision (TME) principle, achieving R0 resection. The patient recovered uneventfully without perioperative complications, and long-term surveillance was recommended. This case highlights the diagnostic challenges of sporadic rectal MPNST with non-specific symptoms and extremely high proliferative activity, and provides evidence for the feasibility of laparoscopic APR in low rectal MPNST. It also underscores the need for individualized adjuvant therapy and long-term surveillance in high-risk cases.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.