ArticleFrontiers in psychiatry2026
Bioinformatics analysis of the mechanisms and efficacy of the Bushen Anzhi recipe in treating aging-related insomnia.
Article in Frontiers in psychiatry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Chinese herbal medicine has a long history of treating insomnia with excellent curative effects; however, the underlying mechanisms remain unclear. This study discusses the mechanism and curative effects of the main Chinese herbal medicines in the Bushen Anzhi recipe for managing aging-related insomnia (ARI). Methods: The insomnia dataset GSE98582 was obtained from the Gene Expression Omnibus database and included 342 samples from individuals with insomnia and 213 control samples. In total, 931 neuroinflammatory targets were identified in the GeneCards and molecular signatures (MSigDB) databases. The active components corresponding to Results: A total of 25 effective components and 16 neuroinflammation and drug target-related differentially expressed genes were screened. Multi-level network and enrichment analyses showed that Bushen Anzhi mainly regulated cellular biological processes through core target genes such as HIF1A, PTGS2, and GSK3B. Furthermore, compared with the ARI group, the Bushen Anzhi recipe was also found to contribute to increases in total sleep and slow-wave sleep times; significant reductions in escape latency time; increases in fourth quadrant residence time, average movement speed, and amount of wall climbing; reductions in the levels of GSK-3β; and increases in the levels of β-catenin and Wnt3a. Conclusion: The Bushen Anzhi recipe may alleviate ARI through a complex multi-level interaction network, with findings suggesting a potential association with the regulation of the Wnt signaling pathway, though further experimental validation is warranted.
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