ArticleJAC-antimicrobial resistance2026
Fpr1p mediates the synergistic effect of rapamycin or tacrolimus with caspofungin in
Article in JAC-antimicrobial resistance, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Objectives: Caspofungin is an echinocandin antifungal agent that inhibits glucan synthesis, an essential component of the fungal cell wall. Rapamycin and tacrolimus are immunosuppressant drugs that share the same cellular receptor, the peptidyl-prolyl isomerase Fpr1p. This study investigated the interactions between rapamycin or tacrolimus and caspofungin in inhibiting the growth of wild-type Methods: Drug interactions were assessed using the microdilution checkerboard method in liquid medium. The results were analysed using the Fractional Inhibitory Concentration Index (FICI) and Response Surface (RS) modelling via SynergyFinder 3.0. Results: Synergy was consistently observed between caspofungin and tacrolimus, as well as between caspofungin and rapamycin, in the Conclusions: The synergistic effect of caspofungin with tacrolimus and rapamycin in
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