ArticleContemporary clinical trials communications2026
Efficacy of Cognitively-based compassion training for Veterans with chronic pain with psychological Comorbidity: Protocol for a randomized clinical trial.
Article in Contemporary clinical trials communications, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04651296 (Efficacy of Mind-Body Approaches for the Treatment of Chronic Pain With Psychological Comorbidity), which is not on this map. Not yet cited in PubMed.
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Efficacy of Mind-Body Approaches for the Treatment of Chronic Pain With Psychological Comorbidity
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Abstract
Chronic pain with psychological comorbidity, especially posttraumatic stress disorder (PTSD) and/or depression, is a prevalent and costly problem, especially among Veterans. Compassion meditation (CM) is a meditative practice that focuses on developing attentional regulation and the intention to assuage suffering. CM-based approaches show promise in ameliorating physical and mental health problems as well as improving quality of life. The objective of this study, a randomized clinical trial, is to compare the efficacy of Cognitively-Based Compassion Training® for Chronic Pain with Psychological Comorbidity (CBCT-CP+) to Health Education while Living with Pain (H.E.L.P.; health psychoeducation control), among 142 Veterans with chronic pain and psychological comorbidity (PTSD and/or depression). Veterans in both groups will participate in 10 weekly, 90-min virtual group sessions, and will be assessed at baseline (0 weeks), weekly during intervention (weeks 1-10), mid-treatment (between weeks 4 and 5), posttreatment (10 weeks), 3-month and 6-month follow-up. The primary aim is to evaluate the efficacy of CBCT-CP + compared to H.E.L.P. in reducing 1) pain interference (measured with Brief Pain Inventory (BPI)) and 2) severity of comorbid psychopathology (PTSD and/or depression; assessed with the Clinical Global Impression scale (CGI)). We hypothesize that CBCT-CP + will be associated with larger reductions in pain interference and severity of comorbid psychopathology (co-primary outcomes) compared to control. We also hypothesize that CBCT-CP + will be associated with greater improvements in life satisfaction and quality of life (secondary outcomes). If efficacious, CBCT-CP + could be further evaluated via multi-site or hybrid effectiveness trials and, ultimately, could improve treatment outcomes for Veterans with chronic pain (CP) and PTSD and/or depression. This randomized clinical trial is registered at clinicaltrials.gov (ID: NCT04651296).
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