ArticleAmerican journal of clinical and experimental immunology2026
Low-inflammatory macrophage-BMSC crosstalk enhances osteogenesis with attenuation of oxidative stress.
Article in American journal of clinical and experimental immunology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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8 authors.
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Abstract
aimMacrophage-mesenchymal stem cell (MSC) interactions critically influence bone regeneration during periodontitis resolution. While macrophage polarization under strong inflammatory conditions has been well studied, the functional role of macrophages exposed to low-grade inflammatory stimulation and their impact on MSC osteogenesis remain poorly understood.
methodsRAW264.7 macrophages were stimulated with reduced doses of classical M1 inducers to generate a low-inflammatory transitional phenotype (M1
resultsCompared with classically activated M1 macrophages, M1
conclusionMacrophages exposed to low-grade inflammatory stimulation acquire a transitional phenotype with distinct immunomodulatory properties. Direct interaction with these macrophages enhances BMSC osteogenic differentiation, which is associated with reduced intracellular ROS accumulation. These findings suggest that modulation of oxidative stress contributes to macrophage-mediated osteogenesis in low-inflammatory environments, providing insight into immune-regulated bone regeneration during periodontal healing.
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