ArticleJournal of surgical case reports2026
Endoscopic nipple-sparing mastectomy with immediate DIEP flap reconstruction following neoadjuvant chemotherapy for multifocal HER2-positive breast cancer: a case report.
Article in Journal of surgical case reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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6 authors.
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Abstract
Endoscopic nipple-sparing mastectomy (E-NSM) is a minimally invasive approach that enables oncologically sound breast resection whilst minimizing visible scarring. Its application following neoadjuvant chemotherapy (NACT), particularly in combination with immediate autologous reconstruction using a deep inferior epigastric artery perforator (DIEP) flap, remains infrequently reported. We describe a 38-year-old woman with multifocal HER2-positive invasive ductal carcinoma of the right breast who achieved an excellent clinical and radiological response to HER2-directed neoadjuvant chemotherapy. She subsequently underwent E-NSM through a single axillary incision with intraoperative retroareolar frozen section assessment, followed by immediate DIEP flap reconstruction. Final histopathology demonstrated a pathological complete response (ypT0 ypN0; RCB-0). The postoperative course was uneventful, with full nipple-areolar complex viability and a satisfactory aesthetic outcome. This case demonstrates the feasibility and safety of this combined approach in carefully selected patients.
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